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Proteintech
KLF15 Polyclonal Antibody
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Product Details
13749-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLF15 fusion protein Ag4690
Conjugate
Form
Liquid
Concentration
0.7 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: MVDHLLPVDE NFSSPKCPVG YLGDRLVGRR AYHMLPSPVS EDDSDASSPC SCSSPDSQAL CSCYGGGLGT ESQDSILDFL LSQATLGSGG GSGSSIGASS GPVAWGPWRR AAAPVKGEHF CLPEFPLGDP DDVPRPFQPT LEEIEEFLEE NMEPGVKEVP EGNSKDLDAC SQLSAGPHKS HLHPGSSGRE RCSPPPGGAS AGGAQGPGGG PTPDGPIPVL LQIQPVPVKQ ESGTGPASPG QAPENVKVAQ LLVNIQGQTF ALVPQVVPSS NLNLPSKFVR IAPVPIAAKP VGSGPLGPGP AGLLMGQKFP KNPAAELIKM HKCTFPGCSK MYTKSSHLKA HLRRHTGEKP FACTWPGCGW RFSRSDELSR HRRSHSGVKP YQCPVCEKKF ARSDHLSKHI KVHRFPRSSR SVRSVN
Target Information
KLF15 is a nuclear protein belonging to the Sp1 C2H2-type zinc-finger protein family with three C2H2-type zinc fingers. A transcriptional activator, KLF15 binds to the GA element of the CLCNKA promoter and may help to regulate the strict tissue and nephron segment-specific expression of CLCNKA and CLCNKB channel genes. It plays an essential role in adipogenesis in cells through its regulation of PPARG expression. Reports suggest that KLF15 is an inhibitor of cardiac hypertrophy and functions in a pathway, regulating the cardiac response to hemodynamic stress, and regulates mitochondrial acetyl-CoA synthase expression in skeletal muscle. KLF15 may also act as a transcriptional repressor of the rhodopsin and IRBP promoters in the retina, and is a possible participant in repression of photoreceptor-specific gene expression in nonphotoreceptor cells. It is highly expressed in liver, followed by heart, skeletal muscle, and kidney but not expressed in bone marrow or lymphoid tissues.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Cardiovascular Krueppel-like factor; DKFZp779M1320; Kidney-enriched krueppel-like factor; kidney-enriched Kruppel-like factor; KKLF protein; Krueppel-like factor 15; Kruppel-like factor 15
Gene Aliases: 1810013I09Rik; AV048136; AW494632; CKLF; KKLF; KLF15
UniProt ID: (Human) Q9UIH9, (Mouse) Q9EPW2
Entrez Gene ID: (Human) 28999, (Mouse) 66277
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
protein binding
transcription regulatory region DNA binding
metal ion binding
nucleic acid binding
DNA binding
transcription factor activity, sequence-specific DNA binding
C2H2 zinc finger transcription factor
transcription from RNA polymerase II promoter
glial cell differentiation
cardiac muscle hypertrophy in response to stress
glucose transport
positive regulation of transcription from RNA polymerase II promoter
glomerular visceral epithelial cell differentiation
cellular response to peptide
negative regulation of peptidyl-lysine acetylation
transcription, DNA-templated
regulation of transcription, DNA-templated
regulation of gene expression
positive regulation of transcription, DNA-templated
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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