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Bioss

KLF2/4 Polyclonal Antibody

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Product Details

BS-1064R

Applications
Tested Dilution
Publications

Western Blot (WB)

1:200
-

Immunohistochemistry (Paraffin) (IHC (P))

1:200
-

Immunohistochemistry (Frozen) (IHC (F))

1:100-1:500
-

Immunocytochemistry (ICC/IF)

1:50-1:200
-

Flow Cytometry (Flow)

1:20-1:100
-

ELISA (ELISA)

1:500-1:1,000
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

KLH conjugated synthetic peptide derived from human KLF4.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Protein A

Storage buffer

0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol

Contains

0.02% ProClin 300

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

Transcription factor; can act both as activator and as repressor. Binds the 5'-CACCC-3' core sequence. Binds to the promoter region of its own gene and can activate its own transcription. Regulates the expression of key transcription factors during embryonic development. Plays an important role in maintaining embryonic stem cells, and in preventing their differentiation. Required for establishing the barrier function of the skin and for postnatal maturation and maintenance of the ocular surface. Involved in the differentiation of epithelial cells and may also function in skeletal and kidney development. Contributes to the down-regulation of p53/TP53 transcription.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: endothelial Kruppel-like zinc finger protein; Epithelial zinc finger protein EZF; gut Kruppel-like factor; Gut-enriched krueppel-like factor; Krueppel-like factor 2; Krueppel-like factor 4; Kruppel like factor 2; Kruppel like factor 4; Kruppel-like factor 2 (lung); Kruppel-like factor 4 (Gut enriched kruppel-like factor) (Epithelial zinc-finger protein EZF); Kruppel-like factor 4 (gut); Kruppel-like factor LKLF; Kruppel-like zinc finger protein; Lung krueppel-like factor; lung Kruppel-like factor; lung Kruppel-like zinc finger transcription factor; transcription factor; unnamed protein product; zinc finger protein; LKLF

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Gene Aliases: EZF; GKLF; KLF2; KLF4; LKLF; Zie

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UniProt ID: (Human) Q9Y5W3, (Human) O43474, (Mouse) Q60843, (Rat) Q9ET58, (Mouse) Q60793

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Entrez Gene ID: (Human) 10365, (Human) 9314, (Mouse) 16598, (Rat) 306330, (Mouse) 16600, (Rat) 114505

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Function(s)
RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding DNA binding transcription factor activity, sequence-specific DNA binding protein binding zinc ion binding metal ion binding sequence-specific double-stranded DNA binding transcription regulatory region sequence-specific DNA binding transcription factor activity, sequence-specific DNA binding transcription factor recruiting transcription cofactor binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding double-stranded DNA binding beta-catenin binding chromatin DNA binding phosphatidylinositol 3-kinase regulator activity histone deacetylase binding sequence-specific DNA binding RNA polymerase II sequence-specific DNA binding transcription factor binding lncRNA binding promoter-specific chromatin binding nucleic acid binding core promoter proximal region sequence-specific DNA binding core promoter binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding RNA polymerase II transcription factor binding transcriptional activator activity, RNA polymerase II transcription factor binding transcription factor binding transcription regulatory region DNA binding C2H2 zinc finger transcription factor
Process(es)
negative regulation of transcription from RNA polymerase II promoter cell morphogenesis in utero embryonic development regulation of transcription from RNA polymerase II promoter negative regulation of interleukin-6 production erythrocyte homeostasis response to laminar fluid shear stress multicellular organism growth regulation of gene expression, epigenetic vasodilation erythrocyte maturation positive regulation of nitric oxide biosynthetic process positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter positive regulation of retinoic acid receptor signaling pathway positive regulation of protein metabolic process Type I pneumocyte differentiation cellular response to hydrogen peroxide cellular response to interleukin-1 cellular response to tumor necrosis factor cellular response to fluid shear stress cellular response to laminar fluid shear stress cellular stress response to acid chemical negative regulation of sprouting angiogenesis cellular response to endothelin defense response to tumor cell transcription, DNA-templated transcription from RNA polymerase II promoter mesodermal cell fate determination negative regulation of cell proliferation epidermis development epidermal cell differentiation gene expression positive regulation of gene expression negative regulation of gene expression negative regulation of muscle hyperplasia negative regulation of angiogenesis stem cell population maintenance negative regulation of cell migration epithelial cell differentiation post-embryonic camera-type eye development positive regulation of telomere maintenance response to retinoic acid negative regulation of interleukin-8 production negative regulation of heterotypic cell-cell adhesion somatic stem cell population maintenance post-embryonic hemopoiesis regulation of cell proliferation negative regulation of I-kappaB kinase/NF-kappaB signaling fat cell differentiation regulation of cell differentiation negative regulation of transcription, DNA-templated positive regulation of hemoglobin biosynthetic process negative regulation of smooth muscle cell proliferation regulation of axon regeneration epidermis morphogenesis negative regulation of inflammatory response negative regulation of protein kinase B signaling canonical Wnt signaling pathway negative regulation of response to cytokine stimulus establishment of skin barrier negative regulation of ERK1 and ERK2 cascade cellular response to retinoic acid cellular response to growth factor stimulus negative regulation of cell migration involved in sprouting angiogenesis regulation of blastocyst development positive regulation of pri-miRNA transcription from RNA polymerase II promoter positive regulation of sprouting angiogenesis negative regulation of leukocyte adhesion to arterial endothelial cell cellular response to leukemia inhibitory factor negative regulation of G1/S transition of mitotic cell cycle negative regulation of chemokine (C-X-C motif) ligand 2 production negative regulation of extrinsic apoptotic signaling pathway in absence of ligand regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter in response to stress cellular response to organic cyclic compound cellular response to cycloheximide cellular response to peptide response to organic substance negative regulation of phosphatidylinositol 3-kinase signaling cell differentiation negative regulation of NF-kappaB transcription factor activity positive regulation of cellular protein metabolic process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process regulation of phosphatidylinositol 3-kinase activity negative regulation of interleukin-8 biosynthetic process positive regulation of telomerase activity
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