Immunogen sequence: LMFDPVPVKQE AMDPVSVSYP SNYMESMKPN KYGVIYSTPL PEKFFQTPEG LSHGIQMEPV DL
Highest antigen sequence identity to the following orthologs - mouse 92%, rat 94%.
Krueppel-like factors (KLFs) comprise a family of evolutionarily conserved zinc finger-containing transcription factors with diverse regulatory functions in cell growth, proliferation, differentiation and embryogenesis. Individual members of the Sp1-like/KLF family can function either as activators or repressors, depending on which promoter they bind and the coregulators with which they interact. KLF6, also designated Zf9 or CPBP (core promoter-binding protein), and KLF3 are Kruppel-like zinc finger containing transcription factors. KLF6 is rapidly induced during hepatic stellate cell activation and transactivates a reporter gene driven by the collagen I promoter, suggesting KLF6 plays a role in the response to tissue injury. KLF3 may play a role in hematopoiesis.
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Protein Aliases: Basic krueppel-like factor; basic kruppel like factor; basic Kruppel-like factor; CACCC-box-binding protein BKLF; Krueppel-like factor 3; Kruppel-like factor 3 (basic); MGC48279; TEF-2; transcript ch138
Gene Aliases: BKLF; KLF3
UniProt ID: (Human) P57682
Entrez Gene ID: (Human) 51274
Molecular Function: C2H2 zinc finger transcription factor