KLF4 belongs to the krueppel C2H2-type zinc-finger protein family, consisting of three C2H2-type zinc fingers. It functions as a cell cycle checkpoint protein, induces squamous epithelial dysplasia and maintains the integrity of the G2/M checkpoint following DNA damage. KLF4 prevents centrosome amplification following gamma radiation-induced DNA damage and plays a role in the differentiation of epithelial cells and in the development of the skeleton and kidney. The inactivation of KLF4 leads to bladder carcinogenesis and gastric carcinogenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: endothelial Kruppel-like zinc finger protein; Epithelial zinc finger protein EZF; EZF; GKLF; gut Kruppel-like factor; Gut-enriched krueppel-like factor; Krueppel-like factor 4; Kruppel-like factor 4 (Gut enriched kruppel-like factor) (Epithelial zinc-finger protein EZF); Kruppel-like factor 4 (gut); RP11-150J11.1
Gene Aliases: BOS_9305; EZF; GKLF; KLF4; Zie