Sequence homology: Cow: 100%; Dog: 86%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%
KLF-9 is a transcription factor belonging to the Sp 1 C2H2 type zinc finger family. It binds to GC box elements located in the promoter. This binding of the encoded protein to a single GC box inhibits mRNA expression while binding to tandemly repeated GC box elements activates transcription. KLF-9 serves as a key transcriptional regulator for uterine endometrial cell proliferation, adhesion, and differentiation both during pregnancy and tumorigenesis.
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Protein Aliases: basic transcription element binding protein 1; Basic transcription element-binding protein 1; BTE-binding protein 1; GC-box-binding protein 1; Krueppel-like factor 9; Kruppel-like factor 9; Transcription factor BTEB1
Gene Aliases: BTEB; BTEB1; KLF9