KLF-9 is a transcription factor belonging to the Sp 1 C2H2 type zinc finger family. It binds to GC box elements located in the promoter. This binding of the encoded protein to a single GC box inhibits mRNA expression while binding to tandemly repeated GC box elements activates transcription. KLF-9 serves as a key transcriptional regulator for uterine endometrial cell proliferation, adhesion, and differentiation both during pregnancy and tumorigenesis.
Protein Aliases: basic transcription element binding protein 1; Basic transcription element-binding protein 1; BTE-binding protein 1; GC-box-binding protein 1; Krueppel-like factor 9; Kruppel-like factor 9; Transcription factor BTEB1
Gene Aliases: 2310051E17Rik; AA589643; BTEB; BTEB-1; BTEB1; ENSMUSG00000055440; Gm9971; KLF9
UniProt ID: (Human) Q16196
Molecular Function: C2H2 zinc finger transcription factor