KLRG1 (Killer cell lectin-like receptor G1, MAFA, 2F1-Ag) is a homodimeric member of the lectin-like type 2 transmembrane receptor family whose members contain characteristic immunoreceptor tyrosine-based inhibitory motifs (ITIMs) in their cytoplasmic domains. These ITIMs interact with the SH2 domains of protein phosphatases such as SHP-1. KLRG1 is an inhibitory receptor that is expressed on natural killer (NK) cells and certain T cells. NK cells are involved in the lysis of tumor cells and virus-infected cells, and mediate humoral and cell-mediated immune responses.
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Protein Aliases: C-type lectin domain family 15 member A; C-type lectin domain family 15, member A; ITIM-containing receptor MAFA-L; Killer cell lectin-like receptor subfamily G member 1; killer cell lectin-like receptor subfamily G, member 1; MAFA-like receptor; Mast cell function-associated antigen; mast cell function-associated antigen (ITIM-containing); natural killer cell receptor
Gene Aliases: 2F1; CLEC15A; KLRG1; MAFA; MAFA-2F1; MAFA-L; MAFA-LIKE; MAFAL
UniProt ID: (Human) Q96E93
Entrez Gene ID: (Human) 10219
Molecular Function: transmembrane signal receptor