Proteintech

KMO Polyclonal Antibody

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KMO Antibody in Immunocytochemistry (ICC/IF) — Immunofluorescent analysis of (-20°C Ethanol) fixed MCF-7 cells using 10698-1-AP (KMO antibody) at dilution of 1:50 and Alexa Fluor 488-Conjugated AffiniPure Goat Anti-Rabbit IgG (H+L).

KMO Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemistry of paraffin-embedded human kidney tissue slide using 10698-1-AP (KMO Antibody) at dilution of 1:200 (under 40x lens).

KMO Antibody in Western Blot (WB) — Mouse spleen tissue were subjected to SDS PAGE followed by western blot with 10698-1-AP (KMO antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours.

Product Details

10698-1-AP

Applications	Tested Dilution	Publications
Western Blot (WB)	1:500-1:2,000	View 4 publications 4 publications
Immunohistochemistry (IHC)	-	View 2 publications 2 publications
Immunohistochemistry (Paraffin) (IHC (P))	1:100-1:400	-
Immunocytochemistry (ICC/IF)	1:10-1:100	View 5 publications 5 publications

Product Specifications
Species Reactivity	Human, Mouse, Rat
Published species	Human, Mouse, Rat
Host/Isotype	Rabbit / IgG
Class	Polyclonal
Type	Antibody
Immunogen	KMO Fusion Protein Ag1109 (107-407 aa encoded by BC005297) View antigen
Conjugate	Unconjugated
Form	Liquid
Concentration	0.26 mg/mL
Purification	Antigen affinity chromatography
Storage buffer	PBS, pH 7.3, with 50% glycerol
Contains	0.1% sodium azide
Storage conditions	-20°C

Product Specific Information

Immunogen sequence: LSVSRENLN KDLLTAAEKY PNVKMHFNHR LLKCNPEEGM ITVLGSDKVP KDVTCDLIVG CDGAYSTVRS HLMKKPRFDY SQQYIPHGYM ELTIPPKNGD YAMEPNYLHI WPRNTFMMIA LPNMNKSFTC TLFMPFEEFE KLLTSNDVVD FFQKYFPDAI PLIGEKLLVQ DFFLLPAQPM ISVKCSSFHF KSHCVLLGDA AHAIVPFFGQ GMNAGFEDCL VFDELMDKFS NDLSLCLPVF SRLRIPDDHA ISDLSMYNYI EKNMERFLHA IMPSTFIPLY TMVTFSRIRY HEAVQRWHWQ KR (107-407 aa encoded by BC005297)

Target Information

Kynurenine 3-monooxygenase (KMO; EC 1.14.13.9) is an NADPH-dependent flavin monooxygenase that catalyzes the hydroxylation of the L-tryptophan metabolite L-kynurenine to form L-3-hydroxykynurenine.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

The cerebral protective effect and mechanism of action of vitamin B6 adjuvant ceftriaxone in experimental pneumococcal meningitis.

Brain research

Xu G,Liu X,Wang Y

Sat Sep 15 00:00:00 EDT 2018

The cerebral protective effect and mechanism of action of vitamin B6 adjuvant ceftriaxone in experimental pneumococcal meningitis.

Brain research

Xu G,Liu X,Wang Y

Sat Sep 15 00:00:00 EDT 2018

Upregulation of neuronal kynurenine 3-monooxygenase mediates depression-like behavior in a mouse model of neuropathic pain.

Brain, behavior, and immunity

Laumet G,Zhou W,Dantzer R,Edralin JD,Huo X,Budac DP,O'Connor JC,Lee AW,Heijnen CJ,Kavelaars A

Wed Nov 01 00:00:00 EDT 2017

Upregulation of neuronal kynurenine 3-monooxygenase mediates depression-like behavior in a mouse model of neuropathic pain.

Brain, behavior, and immunity

Laumet G,Zhou W,Dantzer R,Edralin JD,Huo X,Budac DP,O'Connor JC,Lee AW,Heijnen CJ,Kavelaars A

Wed Nov 01 00:00:00 EDT 2017

Increased Indoleamine 2,3-Dioxygenase and Quinolinic Acid Expression in Microglia and Müller Cells of Diabetic Human and Rodent Retina.

Investigative ophthalmology & visual science

Hu P,Hunt NH,Arfuso F,Shaw LC,Uddin MN,Zhu M,Devasahayam R,Adamson SJ,Benson VL,Chan-Ling T,Grant MB

Sun Oct 01 00:00:00 EDT 2017

Central Nervous System Infection with Borna Disease Virus Causes Kynurenine Pathway Dysregulation and Neurotoxic Quinolinic Acid Production.

Journal of virology

Formisano S,Hornig M,Yaddanapudi K,Vasishtha M,Parsons LH,Briese T,Lipkin WI,Williams BL

Sat Jul 15 00:00:00 EDT 2017

Tryptophan PET Imaging of the Kynurenine Pathway in Patient-Derived Xenograft Models of Glioblastoma.

Molecular imaging

Guastella AR,Michelhaugh SK,Klinger NV,Kupsky WJ,Polin LA,Muzik O,Juhász C,Mittal S

Tue Dec 13 00:00:00 EST 2016

Tryptophan PET Imaging of the Kynurenine Pathway in Patient-Derived Xenograft Models of Glioblastoma.

Molecular imaging

Guastella AR,Michelhaugh SK,Klinger NV,Kupsky WJ,Polin LA,Muzik O,Juhász C,Mittal S

Tue Dec 13 00:00:00 EST 2016

Loss of Kynurenine 3-Mono-oxygenase Causes Proteinuria.

Journal of the American Society of Nephrology : JASN

Korstanje R,Deutsch K,Bolanos-Palmieri P,Hanke N,Schroder P,Staggs L,Bräsen JH,Roberts IS,Sheehan S,Savage H,Haller H,Schiffer M

Tue Nov 01 00:00:00 EDT 2016

Loss of Kynurenine 3-Mono-oxygenase Causes Proteinuria.

Journal of the American Society of Nephrology : JASN

Korstanje R,Deutsch K,Bolanos-Palmieri P,Hanke N,Schroder P,Staggs L,Bräsen JH,Roberts IS,Sheehan S,Savage H,Haller H,Schiffer M

Tue Nov 01 00:00:00 EDT 2016

Pharmacological kynurenine 3-monooxygenase enzyme inhibition significantly reduces neuropathic pain in a rat model.

Neuropharmacology

Rojewska E,Piotrowska A,Makuch W,Przewlocka B,Mika J

Tue Mar 01 00:00:00 EST 2016

Activation of NAD(P)H oxidase by tryptophan-derived 3-hydroxykynurenine accelerates endothelial apoptosis and dysfunction in vivo.

Circulation research

Wang Q,Zhang M,Ding Y,Wang Q,Zhang W,Song P,Zou MH

Fri Jan 31 00:00:00 EST 2014

Development of LC/MS/MS, high-throughput enzymatic and cellular assays for the characterization of compounds that inhibit kynurenine monooxygenase (KMO).

Journal of biomolecular screening

Winkler D,Beconi M,Toledo-Sherman LM,Prime M,Ebneth A,Dominguez C,Muñoz-Sanjuan I

Sun Sep 01 00:00:00 EDT 2013

Bioinformatics

Protein Aliases: KMO; kmo {ECO:0000312|RGD:620610}; Kynurenine 3-hydroxylase; kynurenine 3-hydroxylase {ECO:0000255|HAMAP-Rule:MF_03018}; Kynurenine 3-monooxygenase; kynurenine 3-monooxygenase {ECO:0000255|HAMAP-Rule:MF_03018}

Gene Aliases: AI046660; dJ317G22.1; KMO

UniProt ID: (Human) O15229, (Mouse) Q91WN4, (Rat) O88867

Entrez Gene ID: (Human) 8564, (Mouse) 98256, (Rat) 59113

Molecular Function: oxygenase