Immunogen sequence: MEMAPGGVIT SDMIEMIFSK SPEQQLSATQ K
Recombination activating proteins RAG1 and RAG2 regulate and mediate VJ recombination, the process by which genes for immunoglobulins and T-cell receptors are generated. Several other ubiquitously expressed proteins are thought to be recruited in the recombination process. Among these are the genes affected in severe combined immune deficiency and genes involved in ds-DNA break repair. The protein encoded by this gene interacts with RAG1 and may play a role in VJ recombination. Two transcript variants, one protein-coding and the other not, have been found for this gene.
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Protein Aliases: importin alpha 5; importin subunit alpha-1; Importin subunit alpha-5; Importin subunit alpha-5, N-terminally processed; importin-alpha-S1; IPOA5; karyopherin alpha 1 (importin alpha 5); Karyopherin subunit alpha-1; NPI-1; Nucleoprotein interactor 1; RAG cohort protein 2; RCH2; recombination activating gene cohort 2; SRP1; SRP1-beta
Gene Aliases: IPOA5; KPNA1; NPI-1; RCH2; SRP1
UniProt ID: (Human) P52294
Entrez Gene ID: (Human) 3836
Molecular Function: transfer/carrier protein