Immunogen sequence: MTTPGKENFR LKSYKNKSLN PDEMRRRREE EGLQLRKQKR EEQLFKRRNV ATAEEETEEE VMSDGGFHEA QISNMEMAPG GVITSDMIEM IFSKSPEQQL SATQKFRKLL SKEPNPPIDE VISTPGVVAR FVEFLKRKEN CTLQFESAWV LTNIASGNSL QTRIVIQAGA VPIFIELLSS EFEDVQEQAV WALGNIAGDS TMCRDYVLDC NILPPLLQLF SKQNRLTMTR NAVWALSNLC RGKSPPPEFA KVSPCLNVLS WLLFVSDTDV LADACWALSY LSDGPNDKIQ AVIDAGVCRR; Positive Samples: MCF-7, K-562, HepG2, HeLa, A-549, Mouse brain, Mouse heart; Cellular Location: Cytoplasm, Nucleus
The transport of molecules between the nucleus and the cytoplasm in eukaryotic cells is mediated by the nuclear pore complex (NPC), which consists of 60-100 proteins. Small molecules (up to 70 kD) can pass through the nuclear pore by nonselective diffusion while larger molecules are transported by an active process. The protein encoded by this gene belongs to the importin alpha family, and is involved in nuclear protein import. This protein interacts with the recombination activating gene 1 (RAG1) protein and is a putative substrate of the RAG1 ubiquitin ligase. Alternative splicing results in multiple transcript variants.
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Protein Aliases: importin alpha 5; importin alpha-5; Importin alpha-S1; importin subunit alpha-1; Importin subunit alpha-5; Importin subunit alpha-5, N-terminally processed; importin-alpha-S1; karyopherin (importin) alpha 1; karyopherin alpha 1 (importin alpha 5); Karyopherin subunit alpha-1; karyopherin/importin alpha-1; m-importin-alpha-S1; NPI-1; Nucleoprotein interactor 1; RAG cohort protein 2; recombination activating gene cohort 2; SRP1-beta
Gene Aliases: AW494490; IPOA5; KPNA1; mSRP1; NPI-1; NPI1; RCH2; SRP1
Molecular Function: transfer/carrier protein