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Invitrogen
KPNA1 Polyclonal Antibody
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FIGURE: 1 / 4
KPNA1 Antibody (PA5-95913) in IHC (P)
Immunohistochemistry analysis of KPNA1 in paraffin-embedded human lung cancer. Samples were incubated with KPNA1 Polyclonal antibody (Product # PA5-95913) using a dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol.
Product Details
PA5-95913
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human KPNA1 (NP_0022553)
Conjugate
Form
Liquid
Concentration
0.46 mg/mL
Amount
46 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: MTTPGKENFR LKSYKNKSLN PDEMRRRREE EGLQLRKQKR EEQLFKRRNV ATAEEETEEE VMSDGGFHEA QISNMEMAPG GVITSDMIEM IFSKSPEQQL SATQKFRKLL SKEPNPPIDE VISTPGVVAR FVEFLKRKEN CTLQFESAWV LTNIASGNSL QTRIVIQAGA VPIFIELLSS EFEDVQEQAV WALGNIAGDS TMCRDYVLDC NILPPLLQLF SKQNRLTMTR NAVWALSNLC RGKSPPPEFA KVSPCLNVLS WLLFVSDTDV LADACWALSY LSDGPNDKIQ AVIDAGVCRR; Positive Samples: MCF7, K-562, HepG2, HeLa, A-549, Mouse brain, Mouse heart; Cellular Location: Cytoplasm, Nucleus
Target Information
Recombination activating proteins RAG1 and RAG2 regulate and mediate VJ recombination, the process by which genes for immunoglobulins and T-cell receptors are generated. Several other ubiquitously expressed proteins are thought to be recruited in the recombination process. Among these are the genes affected in severe combined immune deficiency and genes involved in ds-DNA break repair. The protein encoded by this gene interacts with RAG1 and may play a role in VJ recombination. Two transcript variants, one protein-coding and the other not, have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: IMA2; Importin alpha 2; importin alpha 5; Importin alpha P1; importin alpha-5; Importin alpha-S1; importin subunit alpha-1; Importin subunit alpha-5; importin-alpha-S1; IPOA 1; IPOA1; karyopherin (importin) alpha 1; Karyopherin A2; karyopherin alpha 1 (importin alpha 5); Karyopherin subunit alpha-1; karyopherin/importin alpha-1; KPNA1; KPNA2; m-importin-alpha-S1; NPI-1; Nucleoprotein interactor 1; RAG cohort 1; RAG cohort protein 2; RCH 1; RCH1; recombination activating gene cohort 2; SRP 1; SRP1 alpha; SRP1 homolog; SRP1-beta; unnamed protein product
Gene Aliases: AW494490; IPOA5; KPNA1; mSRP1; NPI-1; NPI1; RCH2; SRP1
UniProt ID: (Human) P52294, (Mouse) Q60960
Entrez Gene ID: (Human) 3836, (Mouse) 16646, (Rat) 288064
regulation of DNA recombination
protein import into nucleus
NLS-bearing protein import into nucleus
skeletal muscle satellite cell proliferation
satellite cell activation involved in skeletal muscle regeneration
protein transport
regulation of apoptotic process
skeletal muscle tissue regeneration
regulation of canonical Wnt signaling pathway
postsynapse to nucleus signaling pathway
transport
positive regulation of protein import into nucleus
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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