This Antibody was verified by KnockDown to ensure that the antibody binds to the antigen stated. View Details
PA1-32094 detects KPNA2 from human samples.
PA1-32094 has been successfully used in Western blot applications.
The PA1-32094 immunogen is: Peptide with sequence QVQDGAPGTFNF, from C Terminus of the protein sequence according to NP_002257
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.
The import of proteins into the nucleus is a process that involves at least 2 steps. The first is an energy-independent docking of the protein to the nuclear envelope and the second is an energy-dependent translocation through the nuclear pore complex. Imported proteins require a nuclear localization sequence which generally consists of a short region of basic amino acids or 2 such regions spaced about 10 amino acids apart. Proteins involved in the first step of nuclear import have been identified in different systems. These include the Xenopus protein importin and its yeast homolog, SRP1, which bind to the NLS. KPNA2 protein interacts with the NLSs of DNA helicase Q1 and SV40 T antigen and may be involved in the nuclear transport of proteins. KPNA2 also may play a role in VJ recombination.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Importin alpha P1; Importin subunit alpha-1; importin subunit alpha-2; importin-alpha-P1; IPOA1; karyopherin (importin) alpha 2; karyopherin alpha 2 (RAG cohort 1, importin alpha 1); Karyopherin subunit alpha-2; m-importin-alpha-P1; nuclear import protein; Pendulin; Pore targeting complex 58 kDa subunit; PTAC58; QIP2; RAG cohort protein 1; RCH1; SRP1-alpha; SRP1alpha
Gene Aliases: 2410044B12Rik; importin; IPOA1; KPNA2; PTAC58; QIP2; RCH1; SRP1; SRP1-alpha; SRP1alpha
Molecular Function: transfer/carrier protein