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Invitrogen
KPNA2 Polyclonal Antibody
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FIGURE: 1 / 2
KPNA2 Antibody (PA5-102445) in IHC (P)
Immunohistochemistry analysis of KPNA2 in human ovarian cancer. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. Samples were incubated with KPNA2 polyclonal antibody (Product # PA5-102445) using a dilution of 1:100 (4°C overnight) followed by HRP conjugated anti-Rabbit secondary antibody.
Product Details
PA5-102445
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human KPNA2(Accession P52292), corresponding to amino acid residues D44-L94.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total KPNA2.
Target Information
The import of proteins into the nucleus is a process that involves at least 2 steps. The first is an energy-independent docking of the protein to the nuclear envelope and the second is an energy-dependent translocation through the nuclear pore complex. Imported proteins require a nuclear localization sequence which generally consists of a short region of basic amino acids or 2 such regions spaced about 10 amino acids apart. Proteins involved in the first step of nuclear import have been identified in different systems. These include the Xenopus protein importin and its yeast homolog, SRP1, which bind to the NLS. KPNA2 protein interacts with the NLSs of DNA helicase Q1 and SV40 T antigen and may be involved in the nuclear transport of proteins. KPNA2 also may play a role in VJ recombination.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: IMA2; importin alpha 2; Importin alpha P1; Importin subunit alpha-1; importin subunit alpha-2; importin-alpha-P1; IPOA 1; IPOA1 QIP2; karyopherin (importin) alpha 2; Karyopherin A2; karyopherin alpha 2 (RAG cohort 1, importin alpha 1); Karyopherin subunit alpha-2; m-importin-alpha-P1; nuclear import protein; Pendulin; Pore targeting complex 58 kDa subunit; PTAC58; RAG cohort 1; RAG cohort protein 1; RCH 1; SRP 1; SRP1 alpha; SRP1-alpha
Gene Aliases: 2410044B12Rik; importin; IPOA1; KPNA2; PTAC58; QIP2; RCH1; SRP1; SRP1-alpha; SRP1alpha
UniProt ID: (Human) P52292, (Mouse) P52293
Entrez Gene ID: (Human) 3838, (Mouse) 16647, (Rat) 85245
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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