FIGURE: 1 / 3
A suggested positive control is EL4 cell lysate.
PA5-21035 can be used with blocking peptide PEP-1149.
The transport of molecules between the nucleus and the cytoplasm in eukaryotic cells is mediated by the nuclear pore complex (NPC), which consists of 60-100 proteins. Small molecules (up to 70 kD) can pass through the nuclear pore by nonselective diffusion while larger molecules are transported by an active process. The protein encoded by this gene belongs to the importin alpha family, and is involved in nuclear protein import.
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Protein Aliases: importin alpha 4; Importin alpha Q2; importin alpha-3; importin subunit alpha-3; Importin subunit alpha-4; importin-alpha-Q2; karyopherin (importin) alpha 3; karyopherin alpha 3 (importin alpha 4); Karyopherin subunit alpha-3; predicted role in nuclear import; Qip2; RP11-432M24.3; SRP1-gamma
Gene Aliases: hSRP1; importin; IPOA4; KPNA3; QIP2; SRP1; SRP1gamma; SRP4
Molecular Function: transporter