This antibody is predicted to react with bovine, canine and rat based on sequence homology.
The nuclear import of karyophilic proteins is directed by short amino acid sequences termed nuclear localization signals (NLSs). Karyopherins, or importins, are cytoplasmic proteins that recognize NLSs and dock NLS-containing proteins to the nuclear pore complex. The protein encoded by this gene shares the sequence similarity with Xenopus importin-alpha and Saccharomyces cerevisiae Srp1. This protein is found to interact with the NLSs of DNA helicase Q1 and SV40 T antigen.
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Protein Aliases: importin alpha 3; Importin alpha Q1; Importin subunit alpha-3; importin subunit alpha-4; importin-alpha-Q1; IPOA3; karyopherin (importin) alpha 4; karyopherin alpha 4; karyopherin alpha 4 (importin alpha 3); Karyopherin subunit alpha-4; KPNA4; MGC12217; MGC26703; predicted role in nuclear import; QIP1; SRP3
Gene Aliases: 1110058D08Rik; importin; IPOA3; KPNA4; QIP1; SRP3
Molecular Function: transfer/carrier protein