Immunogen sequence: MADNEKLDNQ RLKNFKNKGR DLETMRRQRN EVVVELRKNK RDEHLLKRRN VPHEDICEDS DIDGDYRVQN TSLEAIVQNA SSDNQGIQLS AVQAARKLLS SDRNPPIDDL IKSGILPILV HCLERDDNPS LQFEAAWALT NIASGTSEQT QAVVQSNAVP LFLRLLHSPH QNVCEQAVWA LGNIIGDGPQ CRDYVISLGV VKPLLSFISP SIPITFLRNV TWVMVNLCRH KDPPPPMETI; Positive Samples: BT-474, A-549, SKOV3, Mouse spleen; Cellular Location: Cytoplasm, Nucleus
The nuclear import of karyophilic proteins is directed by short amino acid sequences termed nuclear localization signals (NLSs). Karyopherins, or importins, are cytoplasmic proteins that recognize NLSs and dock NLS-containing proteins to the nuclear pore complex. The protein encoded by this gene shares the sequence similarity with Xenopus importin-alpha and Saccharomyces cerevisiae Srp1. This protein is found to interact with the NLSs of DNA helicase Q1 and SV40 T antigen.
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Protein Aliases: Importin alpha Q1; Importin subunit alpha-3; importin subunit alpha-4; karyopherin (importin) alpha 4; karyopherin alpha 4 (importin alpha 3); Karyopherin subunit alpha-4; predicted role in nuclear import; Qip1
Gene Aliases: 1110058D08Rik; importin; IPOA3; KPNA4; QIP1; SRP3
Molecular Function: transfer/carrier protein