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|Tested species reactivity||Virus|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide, corresponding to amino acids sequence of KSHV ORF8.|
|Storage buffer||whole serum|
|Storage Conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Tested Applications||Dilution *|
|Western Blot (WB)||1/500 - 1/2000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
PA5-19852 targets KSHV ORF8 in WB applications and shows reactivity with Human samples.
The PA5-19852 immunogen is synthetic peptide, corresponding to amino acids sequence of KSHV ORF8.
Kaposi's sarcoma-associated herpesvirus (KSHV) belongs to the gamma-(2)-herpesvirus subfamily and has been closely linked to the Kaposi"e;s sarcoma, primary effusion lymphoma (PEL) and multicentric Castleman"e;s disease. The genome of KSHV is 165-170 kb and contains at least 88 open reading frames. KSHV ORF8 is a virion envelope-associated protein. Akula et al (2003) report it acts as a Glycoprotein B mediated signaling during virus entry. This Glycoprotein possesses the Arg-Gly-Asp (RGD) motif and utilizes alpha3beta1 integrin as one of the receptors for its entry into the target cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Kaposi's sarcoma-associated herpesvirus