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Invitrogen
KSR2 Polyclonal Antibody
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Product Details
PA5-101188
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human KSR2(Accession Q6VAB6), corresponding to amino acid residues K674-L724.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total KSR2.
Target Information
KSR2 serine/threonine kinase or kinase suppressor of Ras 2 specifically regulates the activity of MEKK3 and COT but not other members of the MAP3K family. KSR interacts with a regulatory Raf molecule in cis to induce a conformational switch of MEK, facilitating MEK's phosphorylation by a separate catalytic Raf molecule in trans. Blocks MAP3K8 kinase activity and MAP3K8- mediated signaling. Acts as a negative regulator of MAP3K3- mediated activation of ERK, JNK and NF-kappa-B pathways, inhibiting MAP3K3-mediated interleukin-8 production.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: hKSR-2; hKSR2; Kinase suppressor of Ras 2; ksr2; testes-kinase suppressor of ras 2 isoform; unnamed protein product
Gene Aliases: KSR2
UniProt ID: (Human) Q6VAB6, (Mouse) Q3UVC0
Entrez Gene ID: (Human) 283455, (Mouse) 333050
nucleotide binding
protein kinase activity
protein serine/threonine kinase activity
MAP-kinase scaffold activity
protein binding
ATP binding
zinc ion binding
kinase activity
transferase activity
mitogen-activated protein kinase kinase binding
metal ion binding
protein serine kinase activity
transferase activity, transferring phosphorus-containing groups
non-receptor serine/threonine protein kinase
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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