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Invitrogen
Kalirin Polyclonal Antibody
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Product Details
PA5-99843
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human KALRN(Accession O60229), corresponding to amino acid residues F1657-C1707.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total KALRN.
Target Information
HAP1 (huntingtin-associated protein 1) binds to huntingtin. Huntingtin is a protein that contains a polyglutamine region and when the number of glutamine repeats exceeds 35, the gene encodes a version of huntingtin that leads to Huntington's disease (HD). The ability of HAP1 to bind to huntingtin is enhanced by an expanded polyglutamine repeat region. HAP1 shows neuronal localization and moves with huntingtin in nerve fibers. HAP1 is primarily expressed in brain tissue, with greater expression in the olfactory bulb and brain stem. Mouse HAP1 is localized to membrane-bound organelles including large endosomes, tubulovesicular structures and budding vesicles in neurons. Duo, also designated huntingtin-associated protein interacting protein or HAPIP, binds Huntingtin-associated protein 1 (HAP1) and may have a role in vesicle trafficking and cytoskeletal function.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: cyclin B1; FLJ12332; FLJ16443; FLJ18196; FLJ18623; hCG_2022551; huntingtin-associated protein interacting protein (duo); Huntingtin-associated protein-interacting protein; Kalirin; kalrn; P-CIP10; PAM COOH-terminal interactor protein 10; Protein Duo; RhoGEF kinase; serine/threonine kinase with Dbl- and pleckstrin homology domain; serine/threonine kinase with Dbl- and pleckstrin homology domains; Serine/threonine-protein kinase with Dbl- and pleckstrin homology domain
Gene Aliases: 2210407G14Rik; ARHGEF24; AV235988; CHD5; CHDS5; DUET; DUO; E530005C20Rik; Gm539; HAPIP; Kalirin; KALRN; TRAD
UniProt ID: (Human) O60229, (Rat) P97924, (Mouse) A2CG49
Entrez Gene ID: (Human) 8997, (Rat) 84009, (Mouse) 545156
protein serine/threonine kinase activity
guanyl-nucleotide exchange factor activity
Rho guanyl-nucleotide exchange factor activity
GTPase activator activity
ATP binding
metal ion binding
protein binding
enzyme binding
nucleotide binding
protein kinase activity
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
guanyl-nucleotide exchange factor
non-receptor serine/threonine protein kinase
protein phosphorylation
signal transduction
nervous system development
vesicle-mediated transport
regulation of Rho protein signal transduction
intracellular signal transduction
positive regulation of apoptotic process
positive regulation of GTPase activity
ephrin receptor signaling pathway
regulation of small GTPase mediated signal transduction
axonogenesis
regulation of dendrite development
phosphorylation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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