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Invitrogen
Kininogen Light Chain Polyclonal Antibody
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FIGURE: 1 / 3
Kininogen Light Chain Antibody (PA5-98322) in ICC/IF
Immunofluorescent analysis of Kininogen Light Chain in HepG2 cells using a Kininogen Light Chain polyclonal antibody (Product # PA5-98322) at a dilution of 1:100. Alexa Fluor 488-congugated Goat Anti-Rabbit IgG(H+L) secondary antibody was used.
Product Details
PA5-98322
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Human Kininogen-1 protein (390-644AA)
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein G
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.03% ProClin 300
Storage conditions
-20°C or -80°C if preferred
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
This gene uses alternative splicing to generate two different proteins- high molecular weight kininogen (HMWK) and low molecular weight kininogen (LMWK). HMWK is essential for blood coagulation and assembly of the kallikrein-kinin system. Also, bradykinin, a peptide causing numerous physiological effects, is released from HMWK. In contrast to HMWK, LMWK is not involved in blood coagulation. Three transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Alpha-2-thiol proteinase inhibitor; bradykinin; Fitzgerald factor; High molecular weight kininogen; HMWK; Kininogen-1; prepro alpha-2-thiol proteinase inhibitor; unnamed protein product; Williams-Fitzgerald-Flaujeac factor
Gene Aliases: BDK; BK; HAE6; HK; HMWK; KNG; KNG1
UniProt ID: (Human) P01042
Entrez Gene ID: (Human) 3827
inflammatory response
negative regulation of cell adhesion
signal transduction
positive regulation of cytosolic calcium ion concentration
blood coagulation
hemostasis
negative regulation of blood coagulation
killing of cells of other organism
vasodilation
positive regulation of apoptotic process
negative regulation of proteolysis
negative regulation of multicellular organismal process
antimicrobial humoral immune response mediated by antimicrobial peptide
regulation of blood vessel diameter
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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