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Invitrogen
Applications | Tested Dilution | Publications |
---|---|---|
Western Blot (WB) |
1-2 µg/mL | View 4 publications 4 publications |
Immunohistochemistry (IHC) |
2.5 µg/mL | - |
Immunocytochemistry (ICC/IF) |
- | View 1 publication 1 publication |
Neutralization (Neu) |
- | View 1 publication 1 publication |
Product Specifications | |
---|---|
Species Reactivity |
Human, Mouse, Rat |
Published species |
Human, Mouse |
Host/Isotype |
Rabbit / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
A 17 amino acid peptide near the center of human KLOTHO. |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
1 mg/mL |
Purification |
Antigen affinity chromatography |
Storage buffer |
PBS |
Contains |
0.02% sodium azide |
Storage conditions |
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C |
RRID |
AB_11153007 |
A suggested positive control is HepG2 cell lysate.
PA5-21078 can be used with blocking peptide PEP-1192.
KLOTHO is the systemic anti-aging hormone within the glycosidase1 superfamily. It encodes a type I membrane protein that is abundant in the kidney and brain. In mice, a deficiency in KLOTHO expression leads to various systemic phenotypes resembling human aging such as arteriosclerosis, osteoporosis, and skin atrophy together with growth retardation, short life-span and infertility. Transgenic mice overexpressing KLOTHO have an extended life span by inhibiting insulin/IGF1 signaling. KLOTHO is involved in the regulation of calcium/phosphorus homeostasis by inhibiting the synthesis of active vitamin D and identified as a potential tumor suppressor.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: HFTC3; Klotho; Klotho peptide; secreted form of Klotho protein
Gene Aliases: alpha-kl; KL
UniProt ID: (Human) Q9UEF7, (Rat) Q9Z2Y9, (Mouse) O35082
Entrez Gene ID: (Human) 9365, (Rat) 83504, (Mouse) 16591
Molecular Function:
glycosidase
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