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Invitrogen

Ku70 Polyclonal Antibody

View all (33) Ku70 antibodies

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Product Details

PA5-87005

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-

Immunocytochemistry (ICC/IF)

1:50-1:200
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide of human Ku70.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2803760

Product Specific Information

Purity is > 95% by SDS-PAGE.

Target Information

XRCC6 is a nuclear complex consisting of two subunits with molecular masses of approximately 70 and 80 kDa. The complex functions as a single-stranded DNA-dependent ATP-dependent helicase. The complex may be involved in the repair of nonhomologous DNA ends such as that required for double-strand break repair, transposition, and V(D)J recombination. High levels of autoantibodies to p70 and p80 have been found in some patients with systemic lupus erythematosus.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: 5'-deoxyribose-5-phosphate lyase Ku70; 5'-dRP lyase Ku70; 5'-dRP/AP lyase Ku70; 70 kDa subunit of Ku antigen; ATP-dependent DNA helicase 2 subunit 1; ATP-dependent DNA helicase II 70 kDa subunit; ATP-dependent DNA helicase II, 70 kDa subunit; CT; CTA-216E10.7; CTC box binding factor 75 kDa subunit; CTC box-binding factor 75 kDa subunit; CTC75; CTCBF; DNA repair protein Ku70; DNA repair protein XRCC6; G22P1; Ku autoantigen p70 subunit; Ku autoantigen protein p70 homolog; Ku autoantigen, 70kDa; Ku p70; Ku protein subunit; Ku70; Ku70 DNA-binding component of DNA-dependent proteinkinase complex (thyroid autoantigen 70 kDa); Lupus Ku autoantigen protein p70; OTTHUMP00000028581; p70 autoantigen; thyroid autoantigen; thyroid autoantigen 70 kDa; thyroid autoantigen 70kD (Ku antigen); thyroid autoantigen 70kDa (Ku antigen); Thyroid-lupus autoantigen; thyroid-lupus autoantigen p70; TLAA; unnamed protein product; X-ray repair complementing defective repair in Chinese hamster cells 6; X-ray repair cross-complementing protein 6

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Gene Aliases: 70kDa; CTC75; CTCBF; G22P1; KU70; Kup70; ML8; TLAA; XRCC6

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UniProt ID: (Human) P12956, (Mouse) P23475

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Entrez Gene ID: (Human) 2547, (Rat) 25019, (Mouse) 14375

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Function(s)
nucleotide binding transcription regulatory region sequence-specific DNA binding DNA binding DNA helicase activity damaged DNA binding double-stranded DNA binding double-stranded telomeric DNA binding RNA binding catalytic activity helicase activity protein binding ATP binding DNA-dependent ATPase activity hydrolase activity lyase activity ATPase activity cyclin binding telomeric DNA binding macromolecular complex binding DNA end binding 5'-deoxyribose-5-phosphate lyase activity scaffold protein binding ATP-dependent DNA helicase activity protein C-terminus binding transcription regulatory region DNA binding poly(A) RNA binding DNA helicase
Process(es)
telomere maintenance recombinational repair activation of innate immune response immune system process positive regulation of immune system process DNA repair double-strand break repair via nonhomologous end joining DNA recombination cellular response to DNA damage stimulus response to ionizing radiation negative regulation of macromolecule biosynthetic process innate immune response positive regulation of lymphocyte differentiation positive regulation of protein kinase activity negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter regulation of smooth muscle cell proliferation cellular hyperosmotic salinity response cellular response to gamma radiation cellular response to X-ray double-strand break repair via classical nonhomologous end joining double-strand break repair brain development DNA duplex unwinding V(D)J recombination positive regulation of neurogenesis transcription, DNA-templated regulation of transcription, DNA-templated metabolic process
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