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Product Details
13025-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Not Applicable
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
L-Plastin Fusion Protein Ag3571 (278-627 aa encoded by BC010271)
Conjugate
Form
Liquid
Concentration
0.13 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: LENAGCNKI GNFSTDIKDS KAYYHLLEQV APKGDEEGVP AVVIDMSGLR EKDDIQRAEC MLQQAERLGC RQFVTATDVV RGNPKLNLAF IANLFNRYPA LHKPENQDID WGALEGETRE ERTFRNWMNS LGVNPRVNHL YSDLSDALVI FQLYEKIKVP VDWNRVNKPP YPKLGGNMKK LENCNYAVEL GKNQAKFSLV GIGGQDLNEG NRTLTLALIW QLMRRYTLNI LEEIGGGQKV NDDIIVNWVN ETLREAEKSS SISSFKDPKI STSLPVLDLI DAIQPGSINY DLLKTENLND DEKLNNAKYA ISMARKIGAR VYALPEDLVE VNPKMVMTVF ACLMGKGMKR V (278-627 aa encoded by BC010271)
Target Information
L-plastin is a leukocyte specific actin bundling protein from fimbrin family of proteins. It has two actin-binding domains and two EF hand type calcium-binding domains. It gets phosphorylated on the serine residue in its headpiece region in response to a variety of inflammatory stimuli. It is hypothesized that L-plastin may play a role in regulating integrin mediated adhesion in leukocytes. L-plastin is expressed in majority of human cancer cell lines derived from solid tumors. Its expression is positively upregulated by testosterones in androgen receptor positive prostrate and breast cancer cells through three androgen receptor binding elements located in the upstream region of the gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: 65 kDa macrophage protein; bA139H14.1 (lymphocyte cytosolic protein 1 (L-plastin)); DKFZp781A23186; epididymis secretory protein Li 37; FLJ25423; FLJ26114; FLJ39956; L-fimbrin; L-plastin; L-plastin (Lymphocyte cytosolic protein 1) (LCP-1) (65 kDa macrophage protein) (PP65); L-plastin (Lymphocyte cytosolic protein 1) (LCP-1) (LC64P); LC64P; LCP-1; Lymphocyte cytosolic protein 1; lymphocyte cytosolic protein 1 (L-plastin); Lymphocyte cytosolic protein-1 (plasmin); plastin 2; plastin 2, L; Plastin-2; pp65
Gene Aliases: AW536232; CP64; D14Ertd310e; HEL-S-37; L-PLASTIN; LC64P; LCP-1; LCP1; LPL; PLS2; pp65
UniProt ID: (Human) P13796, (Mouse) Q61233
Entrez Gene ID: (Human) 3936, (Mouse) 18826, (Rat) 306071
T cell activation involved in immune response
protein kinase A signaling
cell migration
extracellular matrix disassembly
organ regeneration
regulation of intracellular protein transport
wound healing, spreading of cells
actin filament bundle assembly
positive regulation of podosome assembly
response to wounding
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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