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L-VOCC Polyclonal Antibody

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Antibody Testing Data (9)

L-VOCC Antibody in Immunohistochemistry (Paraffin) (IHC (P))

FIGURE: 1 / 9

L-VOCC Antibody (21774-1-AP) in IHC (P)

Immunohistochemical analysis of paraffin-embedded Mouse brain tissue slide using (Product # 21774-1-AP) L-VOCC antibody at dilution of 1:400 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

L-VOCC Antibody in Immunohistochemistry (PFA fixed) (IHC (PFA))

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Product Details

21774-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000-1:4,000

View 16 publications 16 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Immunohistochemistry (PFA fixed) (IHC (PFA))

1:400

Immunocytochemistry (ICC/IF)

View 3 publications 3 publications

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

L-VOCC Fusion Protein Ag16455 (1835-2135 aa encoded by BC146846)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.29 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: EVKMNHDTE ACSEPSLLST EMLSYQDDEN RQLTLPEEDK RDIRQSPKRG FLRSASLGRR ASFHLECLKR QKDRGGDISQ KTVLPLHLVH HQALAVAGLS PLLQRSHSPA SFPRPFATPP ATPGSRGWPP QPVPTLRLEG VESSEKLNSS FPSIHCGSWA ETTPGGGGSS AARRVRPVSL MVPSQAGAPG RQFHGSASSL VEAVLISEGL GQFAQDPKFI EVTTQELADA CDMTIEEMES AADNILSGGA PQSPNGALLP FVNCRDAGQD RAGGEEDAGC VRARGRPSEE ELQDSRVYVS SL (1835-2135 aa encoded by B C146846)

Target Information

CACNA1C encodes an alpha-1 subunit of a voltage-dependent calcium channel. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization. The alpha-1 subunit consists of 24 transmembrane segments and forms the pore through which ions pass into the cell. The calcium channel consists of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. There are multiple isoforms of each of these proteins, either encoded by different genes or the result of alternative splicing of transcripts. The protein encoded by CACNA1C binds to and is inhibited by dihydropyridine. Alternative splicing results in many transcript variants encoding different proteins.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Perinatal Fat-Diets Increased Angiotensin II-Mediated Ca²⁺ through PKC-L-Type Calcium Channel Axis in Resistance Arteries via Agtr1a-Prkcb Gene Methylation.

Nutrients

Zheng Q,He Y,Li L,Rui C,Li N,Zhang Y,Ye Y,Zhang Z,Yang X,Tang J,Xu Z

Tue Jan 03 00:00:00 EST 2023

Berberine attenuates sunitinib-induced cardiac dysfunction by normalizing calcium regulation disorder via SGK1 activation.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association

Li C,Wu W,Xing J,Yan W,Zhang J,Sun J,Zhang Z,Qiu S,Xu Y,Wang X

Mon May 01 00:00:00 EDT 2023

Anthracycline-Induced Atrial Structural and Electrical Remodeling Characterizes Early Cardiotoxicity and Contributes to Atrial Conductive Instability and Dysfunction.

Antioxidants & redox signaling

Tan R,Cong T,Xu G,Hao Z,Liao J,Xie Y,Lin Y,Yang X,Li Q,Liu Y,Xia YL

Fri Jul 01 00:00:00 EDT 2022

Chronic Administration of COVID-19 Drugs Fluvoxamine and Lopinavir Shortens Action Potential Duration by Inhibiting the Human Ether-à-go-go-Related Gene and Cav1.2.

Frontiers in pharmacology

Zheng Z,Cai D,Fu Y,Wang Y,Song Y,Lian J

Tue Jul 26 00:00:00 EDT 2022

Calcium released by osteoclastic resorption stimulates autocrine/paracrine activities in local osteogenic cells to promote coupled bone formation.

American journal of physiology. Cell physiology

Ahmed ASI,Sheng MHC,Lau KW,Wilson SM,Wongworawat MD,Tang X,Ghahramanpouri M,Nehme A,Xu Y,Abdipour A,Zhang XB,Wasnik S,Baylink DJ

Sun May 01 00:00:00 EDT 2022

Pinocembrin alleviates the susceptibility to atrial fibrillation in isoproterenol-induced rats.

Biochemical and biophysical research communications

Liu Z,Chen X,Ye T,Wan W,Yu Y,Zhang C,Yang B

Sun Dec 25 00:00:00 EST 2022

Pinocembrin mediates antiarrhythmic e¿ects in rats with isoproterenol-induced cardiac remodeling.

European journal of pharmacology

Chen X,Wan W,Ran Q,Ye T,Sun Y,Liu Z,Liu X,Shi S,Qu C,Zhang C,Yang B

Tue Apr 05 00:00:00 EDT 2022

Methylation-reprogrammed CHRM3 results in vascular dysfunction in the human umbilical vein following IVF-ET†.

Biology of reproduction

Shi Y,Liu J,Zhu D,Lu L,Zhang M,Li W,Zeng H,Yu X,Guo J,Zhang Y,Zhou X,Gao Q,Xia F,Chen Y,Li M,Sun M

Tue Apr 26 00:00:00 EDT 2022

Harm of circadian misalignment to the hearts of the adolescent wistar rats.

Journal of translational medicine

Wang Y,Hou Y,Song S,Zuo Y,Yu Y,Chi Y,Zhang T

Sat Aug 06 00:00:00 EDT 2022

Harm of circadian misalignment to the hearts of the adolescent wistar rats.

Journal of translational medicine

Wang Y,Hou Y,Song S,Zuo Y,Yu Y,Chi Y,Zhang T

Sat Aug 06 00:00:00 EDT 2022

Cytosolic peptides encoding Ca_V1 C-termini downregulate the calcium channel activity-neuritogenesis coupling.

Communications biology

Yang Y,Yu Z,Geng J,Liu M,Liu N,Li P,Hong W,Yue S,Jiang H,Ge H,Qian F,Xiong W,Wang P,Song S,Li X,Fan Y,Liu X

Thu May 19 00:00:00 EDT 2022

Interleukin-6-Mediated-Ca²⁺ Handling Abnormalities Contributes to Atrial Fibrillation in Sterile Pericarditis Rats.

Frontiers in immunology

Liao J,Zhang S,Yang S,Lu Y,Lu K,Wu Y,Wu Q,Zhao N,Dong Q,Chen L,Du Y

Mon Feb 14 00:00:00 EST 2022

Effects of Angiotensin Receptor-Neprilysin Inhibitor in Arrhythmogenicity Following Left Atrial Appendage Closure in an Animal Model.

Cardiovascular drugs and therapy

Cheng WH,Lugtu IC,Chang SL,Liu SH,Chen SA,Lo LW

Sun Aug 01 00:00:00 EDT 2021

Exosomal miR-29b found in aqueous humour mediates calcium signaling in diabetic patients with cataract.

International journal of ophthalmology

Gao C,Liu X,Fan F,Yang JN,Zhou XY,Mei HJ,Lin XL,Luo Y

Fri Oct 22 00:00:00 EDT 2021

Evidence of Ventricular Arrhythmogenicity and Cardiac Sympathetic Hyperinnervation in Early Cirrhotic Cardiomyopathy.

Frontiers in physiology

Liu SH,Lo LW,Chou YH,Lin WL,Tsai TY,Cheng WH,Lin YJ,Chang SL,Hu YF,Chung FP,Huang HC,Chen SA

Tue Dec 28 00:00:00 EST 2021

In utero hypoxia altered Ang II-induced contraction via PKCβ in fetal cerebral arteries.

The Journal of endocrinology

Su H,Chen X,Zhang Y,Qi L,He Y,Lv J,Zhang Y,Li X,Tang J,Xu Z

Wed Jan 01 00:00:00 EST 2020

Prenatal hypoxia attenuated contraction of offspring coronary artery associated with decreased PKCβ Ser⁶⁶⁰ phosphorylation and intracellular calcium.

Life sciences

Chen X,Qi L,Su H,He Y,Li N,Gao Q,Li H,Xu T,Lu L,Xu Z,Tang J

Sun Nov 15 00:00:00 EST 2020

Protective role and mechanism of snakegourd peel against myocardial infarction in rats.

Phytomedicine : international journal of phytotherapy and phytopharmacology

Yang G,Min D,Yan J,Yang M,Lin G

Thu Mar 15 00:00:00 EDT 2018

Protective role and mechanism of snakegourd peel against myocardial infarction in rats.

Phytomedicine : international journal of phytotherapy and phytopharmacology

Yang G,Min D,Yan J,Yang M,Lin G

Thu Mar 15 00:00:00 EDT 2018

Quercetin Attenuates Ethanol-Induced Iron Uptake and Myocardial Injury by Regulating the Angiotensin II-L-Type Calcium Channel.

Molecular nutrition & food research

Guo X,Chen M,Zeng H,Liu P,Zhu X,Zhou F,Liu J,Zhang J,Dong Z,Tang Y,Gao C,Yao P

Thu Mar 01 00:00:00 EST 2018

Quercetin Attenuates Ethanol-Induced Iron Uptake and Myocardial Injury by Regulating the Angiotensin II-L-Type Calcium Channel.

Molecular nutrition & food research

Guo X,Chen M,Zeng H,Liu P,Zhu X,Zhou F,Liu J,Zhang J,Dong Z,Tang Y,Gao C,Yao P

Thu Mar 01 00:00:00 EST 2018

Bioinformatics

Protein Aliases: brain class C; CACH3; CACN4; CACNA 1D; CACNL1A2; calcium channel voltage-dependent alpha1c subunit; calcium channel, cardic dihydropyridine-sensitive, alpha-1 subunit; Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle; calcium channel, voltage-dependent, alpha 1C subunit; calcium channel, voltage-dependent, L type, alpha 1C subunit; DHP receptor; DHPR, alpha-1 subunit; L-type calcium channel alpha-1 subunit; long-NT; LTCC; MBC; MELC-CC; MGC120730; Mouse brain class C; neuronal voltage-gated calcium channel alpha 1C subunit; Rat brain class C; RBC; skeletal muscle-specific calcium channel; voltage-dependent L-type Ca2+ channel alpha 1 subunit; Voltage-dependent L-type calcium channel subunit alpha-1C; Voltage-gated calcium channel subunit alpha Cav1.2; voltage-gated L-type calcium channel Cav1.2 alpha 1 subunit, splice variant 10*

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Gene Aliases: CACH2; CACN2; CACNA1C; CACNL1A1; CaV1.2; CCHL1A1; D930026N18Rik; LQT8; MBC; MELC-CC; RATIVS302; TS

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UniProt ID: (Human) Q13936, (Mouse) Q01815, (Rat) P22002

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Entrez Gene ID: (Human) 775, (Mouse) 12288, (Rat) 24239

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Function(s)

voltage-gated calcium channel activity protein binding calmodulin binding high voltage-gated calcium channel activity metal ion binding alpha-actinin binding voltage-gated calcium channel activity involved in cardiac muscle cell action potential voltage-gated calcium channel activity involved in AV node cell action potential ion channel activity voltage-gated ion channel activity calcium channel activity enzyme binding protein domain specific binding ion channel binding protein phosphatase 2A binding voltage-gated ion channel

Process(es)

immune system development positive regulation of cytosolic calcium ion concentration heart development regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion embryonic forelimb morphogenesis calcium-mediated signaling using extracellular calcium source camera-type eye development regulation of insulin secretion calcium ion transport into cytosol cardiac conduction calcium ion transmembrane transport via high voltage-gated calcium channel calcium ion transmembrane transport cardiac muscle cell action potential involved in contraction membrane depolarization during cardiac muscle cell action potential membrane depolarization during AV node cell action potential cell communication by electrical coupling involved in cardiac conduction regulation of heart rate by cardiac conduction regulation of ventricular cardiac muscle cell action potential membrane depolarization during atrial cardiac muscle cell action potential transport ion transport calcium ion transport cellular calcium ion homeostasis smooth muscle contraction chemical synaptic transmission adult walking behavior regulation of blood pressure visual learning calcium ion regulated exocytosis regulation of vasoconstriction insulin secretion growth hormone secretion regulation of ion transmembrane transport glucose homeostasis regulation of organ growth transmembrane transport smooth muscle contraction involved in micturition calcium ion import membrane depolarization during action potential

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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L-VOCC Polyclonal Antibody

L-VOCC Antibody (21774-1-AP) in IHC (P)

Product Details

21774-1-AP

Western Blot (WB)

Immunohistochemistry (Paraffin) (IHC (P))

Immunohistochemistry (PFA fixed) (IHC (PFA))

Immunocytochemistry (ICC/IF)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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