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Proteintech
L-VOCC Polyclonal Antibody, CoraLite® Plus 488
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Product Details
CL488-21774
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
L-VOCC fusion protein Ag16455
Conjugate
Excitation/Emission Max
493/522 nm
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol, 0.5% BSA
Contains
0.05% ProClin 300
Storage conditions
-20°C, store in dark
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: EVKMNHDTE ACSEPSLLST EMLSYQDDEN RQLTLPEEDK RDIRQSPKRG FLRSASLGRR ASFHLECLKR QKDRGGDISQ KTVLPLHLVH HQALAVAGLS PLLQRSHSPA SFPRPFATPP ATPGSRGWPP QPVPTLRLEG VESSEKLNSS FPSIHCGSWA ETTPGGGGSS AARRVRPVSL MVPSQAGAPG RQFHGSASSL VEAVLISEGL GQFAQDPKFI EVTTQELADA CDMTIEEMES AADNILSGGA PQSPNGALLP FVNCRDAGQD RAGGEEDAGC VRARGRPSEE ELQDSRVYVS SL
Target Information
CACNA1C encodes an alpha-1 subunit of a voltage-dependent calcium channel. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization. The alpha-1 subunit consists of 24 transmembrane segments and forms the pore through which ions pass into the cell. The calcium channel consists of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. There are multiple isoforms of each of these proteins, either encoded by different genes or the result of alternative splicing of transcripts. The protein encoded by CACNA1C binds to and is inhibited by dihydropyridine. Alternative splicing results in many transcript variants encoding different proteins.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: brain class C; CACH3; CACN4; CACNA 1D; CACNL1A2; calcium channel voltage-dependent alpha1c subunit; calcium channel, cardic dihydropyridine-sensitive, alpha-1 subunit; Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle; calcium channel, voltage-dependent, L type, alpha 1C subunit; DHP receptor; DHPR, alpha-1 subunit; long-NT; LTCC; MBC; MELC-CC; MGC120730; Mouse brain class C; neuronal voltage-gated calcium channel alpha 1C subunit; skeletal muscle-specific calcium channel; voltage-dependent L-type Ca2+ channel alpha 1 subunit; Voltage-dependent L-type calcium channel subunit alpha-1C; Voltage-gated calcium channel subunit alpha Cav1.2; voltage-gated L-type calcium channel Cav1.2 alpha 1 subunit, splice variant 10*
Gene Aliases: CACH2; CACN2; CACNA1C; CACNL1A1; CaV1.2; CCHL1A1; D930026N18Rik; LQT8; MBC; MELC-CC; TS
UniProt ID: (Human) Q13936, (Mouse) Q01815
Entrez Gene ID: (Human) 775, (Mouse) 12288
voltage-gated calcium channel activity
protein binding
calmodulin binding
high voltage-gated calcium channel activity
metal ion binding
alpha-actinin binding
voltage-gated calcium channel activity involved in cardiac muscle cell action potential
voltage-gated calcium channel activity involved in AV node cell action potential
ion channel activity
voltage-gated ion channel activity
calcium channel activity
enzyme binding
protein domain specific binding
ion channel binding
protein phosphatase 2A binding
voltage-gated ion channel
immune system development
positive regulation of cytosolic calcium ion concentration
heart development
regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
embryonic forelimb morphogenesis
calcium-mediated signaling using extracellular calcium source
camera-type eye development
regulation of insulin secretion
calcium ion transport into cytosol
cardiac conduction
calcium ion transmembrane transport via high voltage-gated calcium channel
calcium ion transmembrane transport
cardiac muscle cell action potential involved in contraction
membrane depolarization during cardiac muscle cell action potential
membrane depolarization during AV node cell action potential
cell communication by electrical coupling involved in cardiac conduction
regulation of heart rate by cardiac conduction
regulation of ventricular cardiac muscle cell action potential
membrane depolarization during atrial cardiac muscle cell action potential
transport
ion transport
calcium ion transport
cellular calcium ion homeostasis
smooth muscle contraction
chemical synaptic transmission
adult walking behavior
regulation of blood pressure
visual learning
calcium ion regulated exocytosis
regulation of vasoconstriction
insulin secretion
growth hormone secretion
regulation of ion transmembrane transport
glucose homeostasis
regulation of organ growth
transmembrane transport
smooth muscle contraction involved in micturition
calcium ion import
membrane depolarization during action potential
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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