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L1/ORF2 Polyclonal Antibody
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Product Details
200-901-P11
Product Specifications
Species Reactivity
Mouse
Host/Isotype
Chicken
/ IgY
Class
Polyclonal
Type
Antibody
Immunogen
This IgY fraction antibody was prepared from eggs of chickens laid after repeated immunizations with three synthetic peptides conjugated to keyhole limpet hemocyanin (KLH). The peptides correspond to regions within the endonuclease domain of L1/ORF2 protein.
Conjugate
Form
Liquid
Concentration
1.21 mg/mL
Amount
100 µg
Purification
selective precipitation
Storage buffer
0.02M potassium phosphate, pH 7.2, with 0.15M NaCl
Contains
0.01% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.
Anti-L1/ORF2 Antibody is directed against three regions within the endonuclease domain of L1 ORF2 protein.Reactivity occurs against mouse L1/ORF2 protein and is useful in determining its presence in various assays. A BLAST analysis shows reactivity with L1/ORF2 proteins from mouse sources based on 100% homology with the immunizing sequences. Cross reactivity against L1/ORF2 from other sources is unknown.
Target Information
The L1 (LINE-1), or Long INterspersed Element, retrotransposon ORF2 is the most common open reading frame in the human genome, present in various forms in many thousands of copies. This large family of proteins includes magnesium dependent endonucleases and a large number of phosphatases involved in intracellular signaling. Both intact ORF1 and ORF2 are absolutely required for autonomous retro-transposition. ORF2 encodes an endonuclease, reverse transcriptase, and zinc knuckle domains. The expression of ORF2 appears to be tightly regulated except in germ line tissues, embryonic tissues, and certain cancers including teratomas, testicular cancers, and leukemias. This antibody is intended for use in studying control of L1 retrotransposons.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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