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Invitrogen
L3MBTL1 Polyclonal Antibody
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Product Details
PA5-68930
Product Specifications
Species Reactivity
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
synthetic peptide directed towards the middle region of human L3MBTL1
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS with 2% sucrose
Contains
0.09% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This target displays homology in the following species: Dog: 77%; Guinea Pig: 93%; Horse: 92%; Human: 85%; Mouse: 100%; Rabbit: 85%; Rat: 100%
Target Information
L3MBTL1 is the homolog of a protein identified in Drosophila as a suppressor of malignant transformation of neuroblasts and ganglion-mother cells in the optic centers of the brain. L3MBTL1 is localized to condensed chromosomes in mitotic cells and overexpression of this protein in a glioma cell line results in improper nuclear segregation and cytokinesis producing multinucleated cells. L3MBTL1 represents a polycomb group gene the encoded protein functions to regulate gene activity, likely via chromatin modification. Polycomb group protein specifically recognizes and binds mono- and dimethyllysine residues on target proteins, thereby acting as a reader of a network of post-translational modifications. Alternatively spliced transcript variants encoding different isoforms of the L3MBTL1 gene have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: H-l(3)mbt; H-l(3)mbt protein; L(3)mbt protein homolog; Lethal(3)malignant brain tumor-like protein 1; RP1-138B7.1
Gene Aliases: C630004G01; Kiaa0681; L3mbt; L3mbtl; L3mbtl1; mKIAA0681
UniProt ID: (Mouse) A2A5N8
Entrez Gene ID: (Mouse) 241764
chromatin binding
transcription factor activity, sequence-specific DNA binding
zinc ion binding
nucleosome binding
nucleosomal histone binding
SAM domain binding
methylated histone binding
histone binding
identical protein binding
metal ion binding
chromatin/chromatin-binding, or -regulatory protein
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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