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Active Motif
L3MBTL2 Polyclonal Antibody
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Product Details
39569
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
This L3MBTL2 antibody was raised against a His-Tagged fusion protein containing amino acids 1-230 of human L3MBTL2.
Conjugate
Form
Liquid
Concentration
Conc. Not Determined
Storage buffer
whole serum with 30% glycerol
Contains
0.035% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
The L3MBTL2 gene encodes a protein that belongs to the MBT (malignant brain tumor) family, which is characterized by the presence of MBT domains. These proteins are known for their role in chromatin organization and transcriptional repression. L3MBTL2 specifically acts as a transcriptional repressor, capable of compacting chromatin independent of histone modifications, thereby facilitating gene silencing. Its repressive activity is associated with the suppression of specific target genes, such as CGA in pancreatic cells, indicating its potential role in regulating cellular differentiation and proliferation. The MBT domains in L3MBTL2 are methyl-lysine readers that further contribute to its role in modulating chromatin state, impacting stem cell maintenance and developmental processes. Understanding L3MBTL2's functions and interactions is crucial due to its involvement in maintaining genomic integrity and its implications in cancer biology, particularly in chromatin-mediated gene regulation mechanisms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: dJ756G23.3; H-l(3)mbt-like protein 2; l(3)mbt-like 2; l(3)mbt-like 2 (Drosophila) isoform L3MBTL2_1; l(3)mbt-like 2 (Drosophila) isoform L3MBTL2_2; L(3)mbt-like protein 2; L3MBTL2, polycomb repressive complex 1 subunit; Lethal(3)malignant brain tumor-like protein 2; unnamed protein product
Gene Aliases: H-l(3)mbt-l; L3MBT; L3MBTL2
UniProt ID: (Human) Q969R5
Entrez Gene ID: (Human) 83746
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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