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Proteintech
LACC1 Polyclonal Antibody
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Product Details
27895-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
LACC1 fusion protein Ag27308
Conjugate
Form
Liquid
Concentration
0.35 mg/mL
Amount
52.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: NISYERDGEQ DNCEIETSNG LSALLEEFEI VSCPSMAATL YTIKQKIDEK NLSSIKVIVP RHRKTLMKAF IDQLFTDVYN FEFEDLQVTF RGGLFKQSIE INVITAQELR GIQNEIETFL RSLPALRGKL TIITSSLIPD IFIHGFTTRT GGISYIPTLS SFNLFSSSKR RDPKVVVQEN LRRLANAAGF NVEKFYRIKT HHSNDIWIMG RKEPDSYDG
Target Information
This gene encodes an oxidoreductase that promotes fatty-acid oxidation, with concomitant inflammasome activation, mitochondrial and NADPH-oxidase-dependent reactive oxygen species production, and bactericidal activity of macrophages. The encoded protein forms a complex with fatty acid synthase on peroxisomes and is thought to be modulated by peroxisome proliferator-activated receptor signaling events. Naturally occurring mutations in this gene are associated with inflammatory bowel disease, Behcet's disease, leprosy, ulcerative colitis, early-onset Crohn's disease, and systemic juvenile idiopathic arthritis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Adenosine deaminase LACC1; Fatty acid metabolism-immunity nexus; Guanosine phosphorylase LACC1; Isocyanic acid synthase; laccase (multicopper oxidoreductase) domain containing 1; Laccase domain-containing protein 1; Purine nucleoside phosphorylase LACC1; S-methyl-5'-thioadenosine phosphorylase LACC1; unnamed protein product
Gene Aliases: 9030625A04Rik; C13orf31; FAMIN; JUVAR; LACC1
UniProt ID: (Human) Q8IV20, (Mouse) Q8BZT9
Entrez Gene ID: (Human) 144811, (Mouse) 210808
adenosine deaminase activity
purine-nucleoside phosphorylase activity
copper ion binding
protein binding
oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
transferase activity
hydrolase activity
S-methyl-5-thioadenosine phosphorylase activity
metal ion binding
guanosine phosphorylase activity
molecular_function
pattern recognition receptor signaling pathway
immune system process
positive regulation of cytokine production involved in immune response
inflammatory response
regulation of cellular pH
regulation of defense response
innate immune response
regulation of inflammatory response
nucleotide-binding oligomerization domain containing 2 signaling pathway
regulation of purine nucleotide metabolic process
biological_process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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