|Immunocytochemistry (ICC)||Assay Dependent|
|Immunofluorescence (IF)||Assay dependent|
|Western Blot (WB)||1:250 - 1:1000|
|Immunocytochemistry (ICC)||See 5 publications below|
|Tested Species reactivity||Human|
|Published species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide corresponding to residues C K(407) R S H A G Y Q T I(416) of human LAMP1.|
|Storage buffer||0.02M tris, pH 7.4, with 0.1M glycine|
|Contains||0.1% sodium azide|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
PA1-654A detects Lamp1 from human samples.
PA1-654A has been successfully used in immunofluorescence and Western blotting procedures. In immunofluorescence procedures, this antibody stains Lamp1 in HeLa cells resulting in perinuclear staining.
The PA1-654A immunogen is a synthetic peptide corresponding to residues C K(407) R S H A G Y Q T I(416) of human LAMP1. This region is completely conserved between human, mouse and rat.
Lysosomes are membrane-bound vacuoles which play a critical role in cellular metabolism. These organelles participate in endocytosis, the synthesis and assembly of acid hydrolases, act as sites for digestion of foreign materials and for specialized autolytic cellular processes. Membrane-associated glycoproteins have an important role in normal lysosomal function. Lamp1, also known as lysosome associated membrane protein 1, is a heavily glycosylated membrane protein of the lysosome. It contains a putative signal peptide, 18 sites for N-linked glycosylation, a single membrane-spanning segment and a short (11 amino acid) cytosolic tail.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: CD107 antigen-like family member A; CD107a; LAMP-1; LAMPA; LGP120; lysosomal-associated membrane protein 1; Lysosome-associated membrane glycoprotein 1; lysosome-associated membrane protein 1
Gene Aliases: CD107a; LAMP1; LAMPA; LGP120
UniProt ID: (Human) P11279
Entrez Gene ID: (Human) 3916
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