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Invitrogen
LAMTOR1 Polyclonal Antibody
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Product Details
PA5-114482
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Rabbit polyclonal LAMTOR1 antibody was raised against a 17 amino acid peptide near the amino terminus of human LAMTOR1. The immunogen is located within the first 50 amino acids of LAMTOR1.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Positive controls that may be used include: A431 Cell Lysate, Human Small Intestine Tissue Slide
Target Information
The Ragulator complex is comprised of three proteins, C11orf59, ROBLD3, and MAPKSP1, which targets mTORC1 to lysosomal surfaces. This normal endosomal trafficking is taken advantage of by certain viruses, including coronavirus, which has increased replication when C11orf59 is interfered with. C11orf59 is positively regulated by cellular cholesterol depletion and negatively regulated by cellular cholesterol loading. It is involved in LDL uptake and cholesterol homeostasis. C11orf59 and PPAR-alpha work together to control lipid and carbohydrate metabolism in diabetes. Nearly all effects of C11orf59 are associated with mTORC1 kinase growth promotion, and disregulation of the normal mTOR pathway.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: FLJ20625; Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1; Lipid raft adaptor protein p18; p27kip1 releasing factor from RhoA; p27Kip1-releasing factor from RhoA; p27RF Rho; p27RF-Rho; Protein associated with DRMs and endosomes; Ragulator complex protein LAMTOR1; ragulator complex protein PDRO; RhoA activator C11orf59; RhoA activator C11orf59 homolog; unnamed protein product
Gene Aliases: 2400001E08Rik; C11orf59; LAMTOR1; p18; p27RF-Rho; PDRO; PP7157; Ragulator1
UniProt ID: (Human) Q6IAA8, (Rat) Q6P791, (Mouse) Q9CQ22
Entrez Gene ID: (Human) 55004, (Rat) 308869, (Mouse) 66508
regulation of receptor recycling
endosome organization
lysosome organization
regulation of cholesterol esterification
regulation of cholesterol efflux
cell growth
positive regulation of TOR signaling
lysosome localization
endosome localization
cellular protein localization
cholesterol homeostasis
positive regulation of MAPK cascade
positive regulation of GTPase activity
regulation of cholesterol import
cellular response to amino acid stimulus
autophagosome assembly
regulation of cell growth
cytoplasmic translation
protein localization
negative regulation of autophagy
endosomal transport
cellular response to nutrient levels
TORC1 signaling
negative regulation of translational initiation
positive regulation of translational initiation
protein localization to lysosome
protein localization to membrane
positive regulation of protein localization to lysosome
positive regulation of TORC1 signaling
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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