This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated. View Details
Immunogen sequence: MTSALTQGLE RIPDQLGYLV LSEGAVLASS GDLENDEQAA SAISELVSTA CGFRLHRGMN VPFKRLSVVF GEHTLLVTVS GQRVFVVKRQ NRGREPIDV
Highest antigen sequence identity to the following orthologs: Mouse - 96%, Rat - 97%.
LAMTOR4 is a part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. LAMTOR4 is activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. LAMTOR4 is activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Late endosomal/lysosomal adaptor and MAPK and MTOR activator 4; Ragulator complex protein LAMTOR4; Ragulator complex protein LAMTOR4, N-terminally processed; UPF0539 protein C7orf59; UPF0539 protein C7orf59 homolog
Gene Aliases: 0910001L09Rik; AV006840; C7orf59; LAMTOR4; RGD1309735