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Proteintech
LARGE Polyclonal Antibody
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Product Details
24307-1-AP
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
LARGE Fusion Protein Ag19458 (33-190 aa encoded by BC126404)
Conjugate
Form
Liquid
Concentration
0.23 mg/mL
Amount
34.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: SFEDGKPVS LSPLESQAHS PRYTASSQRE RESLEVRMRE VEEENRALRR QLSLAQGRAP SHRRGNHSKT YSMEEGTGDS ENLRAGIVAG NSSECGQQPV VEKCETIHVA IVCAGYNASR DVVTLVKSVL FHRRNPLHFH LIADSIAEQI LATLFQTWM (33-190 aa encoded by BC126404)
Target Information
The LARGE gene, which is one of the largest in the human genome, encodes a member of the N-acetylglucosaminyltransferase gene family. It encodes a glycosyltransferase which participates in glycosylation of alpha-dystroglycan, and may carry out the synthesis of glycoprotein and glycosphingolipid sugar chains. It may also be involved in the addition of a repeated disaccharide unit. Mutations in this gene cause MDC1D, a novel form of congenital muscular dystrophy with severe mental retardation and abnormal glycosylation of alpha-dystroglycan. Alternative splicing of this gene results in two transcript variants that encode the same protein.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Acetylglucosaminyltransferase-like 1A; acetylglucosaminyltransferase-like protein; Glycosyltransferase-like protein; glycosyltransferase-like protein LARGE1; LARGE; LARGE xylosyl- and glucuronyltransferase 1; like-acetylglucosaminyltransferase; myodystrophy; unnamed protein product; Xylosyl- and glucuronyltransferase LARGE1
Gene Aliases: BPFD#36; enr; fg; froggy; Gyltl1a; KIAA0609; LARGE; LARGE1; Mbp-1; Mbp1; MDC1D; MDDGA6; MDDGB6; mKIAA0609; myd
UniProt ID: (Human) O95461, (Mouse) Q9Z1M7
Entrez Gene ID: (Human) 9215, (Mouse) 16795
catalytic activity
protein binding
acetylglucosaminyltransferase activity
glucuronosyltransferase activity
transferase activity
transferase activity, transferring glycosyl groups
transferase activity, transferring hexosyl groups
manganese ion binding
UDP-xylosyltransferase activity
xylosyltransferase activity
metal ion binding
alpha-1,6-mannosyltransferase activity
alpha-1,2-mannosyltransferase activity
mannosyltransferase activity
alpha-1,3-mannosyltransferase activity
imidazoleglycerol-phosphate synthase activity
alpha-1,3-galactosyltransferase activity
UDP-glucose:glycoprotein glucosyltransferase activity
glycolipid mannosyltransferase activity
oligosaccharyl transferase activity
dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity
acetylgalactosaminyltransferase activity
galactosyltransferase activity
fucosyltransferase activity
O antigen polymerase activity
lipopolysaccharide-1,6-galactosyltransferase activity
cellulose synthase activity
NAD(P)-cysteine ADP-ribosyltransferase activity
NAD(P)-asparagine ADP-ribosyltransferase activity
NAD(P)-serine ADP-ribosyltransferase activity
9-phenanthrol UDP-glucuronosyltransferase activity
1-phenanthrol glycosyltransferase activity
9-phenanthrol glycosyltransferase activity
1,2-dihydroxy-phenanthrene glycosyltransferase activity
phenanthrol glycosyltransferase activity
beta-1,4-mannosyltransferase activity
alpha-1,2-galactosyltransferase activity
dolichyl pyrophosphate Man7GlcNAc2 alpha-1,3-glucosyltransferase activity
lipopolysaccharide-1,5-galactosyltransferase activity
dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity
dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase activity
7-cyano-7-deazaguanine tRNA-ribosyltransferase activity
purine deoxyribosyltransferase activity
inositol phosphoceramide synthase activity
glucosyltransferase activity
alpha-(1->3)-fucosyltransferase activity
alpha-(1->6)-fucosyltransferase activity
indole-3-butyrate beta-glucosyltransferase activity
salicylic acid glucosyltransferase (ester-forming) activity
salicylic acid glucosyltransferase (glucoside-forming) activity
benzoic acid glucosyltransferase activity
chondroitin hydrolase activity
dolichyl-pyrophosphate Man7GlcNAc2 alpha-1,6-mannosyltransferase activity
cytokinin 9-beta-glucosyltransferase activity
glycosyltransferase
blood vessel development
behavioral fear response
neuron migration
N-acetylglucosamine metabolic process
protein glycosylation
protein O-linked glycosylation
protein targeting to membrane
glycosphingolipid biosynthetic process
water transport
intracellular protein transport
striated muscle contraction
plasma membrane organization
cytoskeleton organization
chemical synaptic transmission
neuromuscular synaptic transmission
brain development
heart development
muscle organ development
neuromuscular junction development
sensory perception of sound
memory
protein localization
determination of adult lifespan
glycoprotein metabolic process
glycoprotein biosynthetic process
response to light stimulus
response to mechanical stimulus
gene expression
retina layer formation
myotube differentiation
dentate gyrus development
nerve development
principal sensory nucleus of trigeminal nerve development
macrophage differentiation
post-embryonic hindlimb morphogenesis
multicellular organism growth
protein O-linked mannosylation
protein modification process
myelination
skeletal muscle tissue regeneration
post-translational protein modification
muscle cell cellular homeostasis
regulation of synaptic plasticity
astrocyte differentiation
cardiac muscle tissue development
skeletal muscle fiber development
synapse organization
neuromuscular process controlling posture
neuromuscular process
synaptic growth at neuromuscular junction
localization of cell
striated muscle cell development
cardiac muscle cell development
transmembrane transport
retina development in camera-type eye
limb development
long-term synaptic potentiation
bone development
skeletal muscle organ development
retina vasculature development in camera-type eye
connective tissue development
protein-containing complex assembly
basement membrane organization
potassium ion transmembrane transport
protein localization to membrane
protein localization to plasma membrane
walking behavior
acetylcholine receptor signaling pathway
skeletal muscle fiber differentiation
reactive gliosis
metabolic process
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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