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Proteintech
LARP1 Polyclonal Antibody
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Product Details
13708-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Fruit fly,
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
LARP1 Fusion Protein Ag4645 (1-283 aa encoded by BC033856)
Conjugate
Form
Liquid
Concentration
0.51 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MPRKRKTRH SSNPPLESHV GWVMDSREHR PRTASISSSP SEGTPTVGSY GCTPQSLPKF QHPSHELLKE NGFTQHVYHK YRRRCLNERK RLGIGQSQEM NTLFRFWSFF LRDHFNKKMY EEFKQLALED AKEGYRYGLE CLFRYYSYGL EKKFRLDIFK DFQEETVKDY EAGQLYGLEK FWAFLKYSKA KNLDIDPKLQ EYLGKFRRLE DFRVDPPMGE EGNHKRHSVV AGGGGGEGRK RCPSQSSSRP AAMISQPPTP PTGQPVREDA KWTSQHSNTQ TLGK (1-283 aa encoded by BC033856)
Target Information
RNA-binding protein that regulates the translation of specific target mRNA species downstream of the mTORC1 complex, in function of growth signals and nutrient availability (PubMed:20430826, PubMed:23711370, PubMed:24532714, PubMed:25940091, PubMed:28650797, PubMed:28673543, PubMed:29244122). Interacts on the one hand with the 3' poly-A tails that are present in all mRNA molecules, and on the other hand with the 7-methylguanosine cap structure of mRNAs containing a 5' terminal oligopyrimidine (5'TOP) motif, which is present in mRNAs encoding ribosomal proteins and several components of the translation machinery (PubMed:23711370, PubMed:25940091, PubMed:28650797, PubMed:29244122, PubMed:26206669, PubMed:28379136). The interaction with the 5' end of mRNAs containing a 5'TOP motif leads to translational repression by preventing the binding of EIF4G1 (PubMed:25940091, PubMed:28650797, PubMed:29244122, PubMed:28379136). When mTORC1 is activated, LARP1 is phosphorylated and dissociates from the 5' untranslated region (UTR) of mRNA (PubMed:25940091, PubMed:28650797). Does not prevent binding of EIF4G1 to mRNAs that lack a 5'TOP motif (PubMed:28379136). Interacts with the free 40S ribosome subunit and with ribosomes, both monosomes and polysomes (PubMed:20430826, PubMed:24532714, PubMed:25940091, PubMed:28673543). Under normal nutrient availability, interacts primarily with the 3' untranslated region (UTR) of mRNAs encoding ribosomal proteins and increases protein synthesis (PubMed:23711370, PubMed:28650797). Associates with actively translating ribosomes and stimulates translation of mRNAs containing a 5'TOP motif, thereby regulating protein synthesis, and as a consequence, cell growth and proliferation (PubMed:20430826, PubMed:24532714). Stabilizes mRNAs species with a 5'TOP motif, which is required to prevent apoptosis (PubMed:20430826, PubMed:23711370, PubMed:25940091, PubMed:28673543). [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: CG42551-PA; CG42551-PB; CG42551-PD; CG42551-PE; CG42551-PF; CG42551-PG; CG42551-PH; dLarp; drosophila La related protein; la related protein; La ribonucleoprotein domain family member 1; La ribonucleoprotein domain family, member 1; La-related protein; La-related protein 1; larp-PA; larp-PB; larp-PD; larp-PE; larp-PF; larp-PG; larp-PH; lethal (3) S003108; lethal (3) S022529; meteor
Gene Aliases: 0031/08; 0225/29; 1810024J12Rik; 3110040D16Rik; BcDNA:LD02611; CG14065; CG14066; CG42551; dlarp; Dmel\CG42551; Dmel_CG42551; KIAA0731; l(3)S003108; l(3)S022529; LARP; LARP1; mKIAA0731; RGD1306683
UniProt ID: (Human) Q6PKG0, (Mouse) Q6ZQ58, (Fruit fly) Q9VAW5
Entrez Gene ID: (Human) 23367, (Mouse) 73158, (Rat) 303158, (Fruit fly) 53567
translational initiation
cell proliferation
positive regulation of macroautophagy
TOR signaling
positive regulation of viral genome replication
positive regulation of translation
cell-cell adhesion
mitochondrion inheritance
spindle assembly involved in male meiosis
male meiosis
syncytial blastoderm mitotic cell cycle
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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