RNA-binding protein that promotes translation of specific classes of mRNAs downstream of the mTORC1 complex. Associates with the mRNA 5'cap in an MTOR-dependent manner and associates with mRNAs containing a 5' terminal oligopyrimidine (5'TOP) motif, which is present in mRNAs encoding for ribosomal proteins and several components of the translation machinery. Associates with actively translating ribosomes via interaction with PABPC1/PABP and stimulates translation of mRNAs containing a 5'TOP, thereby regulating cell growth and proliferation. Positively regulates the replication of dengue virus (DENV).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: CG42551-PA; CG42551-PB; CG42551-PD; CG42551-PE; CG42551-PF; CG42551-PG; CG42551-PH; dLarp; drosophila La related protein; KIAA0731; La related protein; La related protein 1; La ribonucleoprotein domain family member 1; La ribonucleoprotein domain family, member 1; La-related protein; La-related protein 1; larp-PA; larp-PB; larp-PD; larp-PE; larp-PF; larp-PG; larp-PH; LARP1; lethal (3) S003108; lethal (3) S022529; meteor
Gene Aliases: 0031/08; 0225/29; 1810024J12Rik; 3110040D16Rik; BcDNA:LD02611; CG14065; CG14066; CG42551; dlarp; Dmel\CG42551; Dmel_CG42551; KIAA0731; l(3)S003108; l(3)S022529; LARP; LARP1; mKIAA0731; RGD1306683