Proteintech

LARP7 Polyclonal Antibody

LARP7 Antibody in Immunocytochemistry (ICC/IF)

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LARP7 Antibody (17067-1-AP) in ICC/IF

Immunofluorescent analysis of ( 10% Formaldehyde ) fixed HeLa cells using 17067-1-AP (LARP7 antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IGG (H+L).

LARP7 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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Product Details

17067-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 9 publications 9 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

1:50-1:500

View 2 publications 2 publications

Immunoprecipitation (IP)

View 2 publications 2 publications

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

LARP7 Fusion Protein Ag10891 (83-331 aa encoded by BC006981)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.13 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: LTTDGKLIA RALRSSAVVE LDLEGTRIRR KKPLGERPKD EDERTVYVEL LPKNVNHSWI ERVFGKCGNV VYISIPHYKS TGDPKGFAFV EFETKEQAAK AIEFLNNPPE EAPRKPGIFP KTVKNKPIPA LRVVEEKKKK KKKKGRMKKE DNIQAKEENM DTSNTSISKM KRSRPTSEGS DIESTEPQKQ CSKKKKKRDR VEASSLPEVR TGKRKRSSSE DAESLAPRSK VKKIIQKDII KEASEASKE (83-331 aa encoded by BC006981)

Target Information

LARP7 gene ontology annotations related to this gene include RNA processing.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Interaction of 7SK with the Smn complex modulates snRNP production.

Nature communications

Ji C,Bader J,Ramanathan P,Hennlein L,Meissner F,Jablonka S,Mann M,Fischer U,Sendtner M,Briese M

Wed Feb 24 00:00:00 UTC 2021

Interaction of 7SK with the Smn complex modulates snRNP production.

Nature communications

Ji C,Bader J,Ramanathan P,Hennlein L,Meissner F,Jablonka S,Mann M,Fischer U,Sendtner M,Briese M

Wed Feb 24 00:00:00 UTC 2021

Interaction of 7SK with the Smn complex modulates snRNP production.

Nature communications

Ji C,Bader J,Ramanathan P,Hennlein L,Meissner F,Jablonka S,Mann M,Fischer U,Sendtner M,Briese M

Wed Feb 24 00:00:00 UTC 2021

Interaction of 7SK with the Smn complex modulates snRNP production.

Nature communications

Ji C,Bader J,Ramanathan P,Hennlein L,Meissner F,Jablonka S,Mann M,Fischer U,Sendtner M,Briese M

Wed Feb 24 00:00:00 UTC 2021

Aberrant miR-1246 expression promotes radioresistance in non-small cell lung cancer: a potential prognostic biomarker and radiotherapy sensitization target.

American journal of cancer research

Fan L,Wang J,Cao Q,Ding X,Li B

Mon Nov 13 00:00:00 UTC 2023

Interaction of the Ankyrin H Core Effector of Legionella with the Host LARP7 Component of the 7SK snRNP Complex.

mBio

Von Dwingelo J,Chung IYW,Price CT,Li L,Jones S,Cygler M,Abu Kwaik Y

Tue Aug 27 00:00:00 UTC 2019

Interaction of the Ankyrin H Core Effector of Legionella with the Host LARP7 Component of the 7SK snRNP Complex.

mBio

Von Dwingelo J,Chung IYW,Price CT,Li L,Jones S,Cygler M,Abu Kwaik Y

Tue Aug 27 00:00:00 UTC 2019

Interaction of the Ankyrin H Core Effector of Legionella with the Host LARP7 Component of the 7SK snRNP Complex.

mBio

Von Dwingelo J,Chung IYW,Price CT,Li L,Jones S,Cygler M,Abu Kwaik Y

Tue Aug 27 00:00:00 UTC 2019

de novo MEPCE nonsense variant associated with a neurodevelopmental disorder causes disintegration of 7SK snRNP and enhanced RNA polymerase II activation.

Scientific reports

Schneeberger PE,Bierhals T,Neu A,Hempel M,Kutsche K

Thu Aug 29 00:00:00 UTC 2019

Human METTL16 is a N⁶-methyladenosine (m⁶A) methyltransferase that targets pre-mRNAs and various non-coding RNAs.

EMBO reports

Warda AS,Kretschmer J,Hackert P,Lenz C,Urlaub H,Höbartner C,Sloan KE,Bohnsack MT

Wed Nov 01 00:00:00 UTC 2017

Human METTL16 is a N⁶-methyladenosine (m⁶A) methyltransferase that targets pre-mRNAs and various non-coding RNAs.

EMBO reports

Warda AS,Kretschmer J,Hackert P,Lenz C,Urlaub H,Höbartner C,Sloan KE,Bohnsack MT

Wed Nov 01 00:00:00 UTC 2017

HMGA1 recruits CTIP2-repressed P-TEFb to the HIV-1 and cellular target promoters.

Nucleic acids research

Eilebrecht S,Le Douce V,Riclet R,Targat B,Hallay H,Van Driessche B,Schwartz C,Robette G,Van Lint C,Rohr O,Benecke AG

Tue Apr 01 00:00:00 UTC 2014

HMGA1 recruits CTIP2-repressed P-TEFb to the HIV-1 and cellular target promoters.

Nucleic acids research

Eilebrecht S,Le Douce V,Riclet R,Targat B,Hallay H,Van Driessche B,Schwartz C,Robette G,Van Lint C,Rohr O,Benecke AG

Tue Apr 01 00:00:00 UTC 2014

Cell cycle gene-specific control of transcription has a critical role in proliferation of primordial germ cells.

Genes & development

Okamura D,Maeda I,Taniguchi H,Tokitake Y,Ikeda M,Ozato K,Mise N,Abe K,Noce T,Izpisua Belmonte JC,Matsui Y

Thu Nov 15 00:00:00 UTC 2012

Cell cycle gene-specific control of transcription has a critical role in proliferation of primordial germ cells.

Genes & development

Okamura D,Maeda I,Taniguchi H,Tokitake Y,Ikeda M,Ozato K,Mise N,Abe K,Noce T,Izpisua Belmonte JC,Matsui Y

Thu Nov 15 00:00:00 UTC 2012

Loss of function mutation in LARP7, chaperone of 7SK ncRNA, causes a syndrome of facial dysmorphism, intellectual disability, and primordial dwarfism.

Human mutation

Alazami AM,Al-Owain M,Alzahrani F,Shuaib T,Al-Shamrani H,Al-Falki YH,Al-Qahtani SM,Alsheddi T,Colak D,Alkuraya FS

Mon Oct 01 00:00:00 UTC 2012

Loss of function mutation in LARP7, chaperone of 7SK ncRNA, causes a syndrome of facial dysmorphism, intellectual disability, and primordial dwarfism.

Human mutation

Alazami AM,Al-Owain M,Alzahrani F,Shuaib T,Al-Shamrani H,Al-Falki YH,Al-Qahtani SM,Alsheddi T,Colak D,Alkuraya FS

Mon Oct 01 00:00:00 UTC 2012

7SK small nuclear RNA directly affects HMGA1 function in transcription regulation.

Nucleic acids research

Eilebrecht S,Brysbaert G,Wegert T,Urlaub H,Benecke BJ,Benecke A

Tue Mar 01 00:00:00 UTC 2011

7SK small nuclear RNA directly affects HMGA1 function in transcription regulation.

Nucleic acids research

Eilebrecht S,Brysbaert G,Wegert T,Urlaub H,Benecke BJ,Benecke A

Tue Mar 01 00:00:00 UTC 2011

7SK snRNA-mediated, gene-specific cooperativity of HMGA1 and P-TEFb.

RNA biology

Eilebrecht S,Benecke BJ,Benecke A

Mon Aug 27 00:00:00 UTC 2012

7SK snRNA-mediated, gene-specific cooperativity of HMGA1 and P-TEFb.

RNA biology

Eilebrecht S,Benecke BJ,Benecke A

Mon Aug 27 00:00:00 UTC 2012

Bioinformatics

Protein Aliases: DKFZP564K112; hLARP7; La ribonucleoprotein domain family member 7; La ribonucleoprotein domain family, member 7; La-related protein 7; P-TEFb-interaction protein for 7SK stability; PIP7S

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Gene Aliases: ALAZS; C330027G06Rik; D3Wsu161e; HDCMA18P; LARP7; PIP7S

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UniProt ID: (Human) Q4G0J3, (Rat) Q5XI01, (Mouse) Q05CL8

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Entrez Gene ID: (Human) 51574, (Rat) 686883, (Mouse) 28036

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Function(s)

nucleotide binding protein binding poly(A) RNA binding RNA binding nucleic acid binding RNA metabolism protein

Process(es)

RNA processing negative regulation of transcription from RNA polymerase II promoter negative regulation of chromatin binding germ cell proliferation positive regulation of G1/S transition of mitotic cell cycle

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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LARP7 Polyclonal Antibody

LARP7 Antibody (17067-1-AP) in ICC/IF

Product Details

17067-1-AP

Western Blot (WB)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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