Immunogen sequence: KWDTERVFEV NASNLEKQTS KGKYFVTFPY PYMNGRLHLG HTFSLSKCEF AVGYQRLKGK CCLFPFGLHC TGMPIKACAD KLK
Highest antigen sequence identity to the following orthologs: Mouse - 89%, Rat - 89%.
This gene encodes a cytosolic leucine-tRNA synthetase, a member of the class I aminoacyl-tRNA synthetase family. The encoded enzyme catalyzes the ATP-dependent ligation of L-leucine to tRNA(Leu). It is found in the cytoplasm as part of a multisynthetase complex and interacts with the arginine tRNA synthetase through its C-terminal domain. Alternatively spliced transcript variants of this gene have been found; however, their full-length nature is not known.
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Protein Aliases: cytoplasmic leucyl-tRNA synthetase; cytosolic leucyl-tRNA synthetase; leucine translase; leucine tRNA ligase 1, cytoplasmic; Leucine--tRNA ligase, cytoplasmic; leucine-tRNA ligase; Leucyl-tRNA synthetase; LeuRS; proliferation-inducing gene 44
Gene Aliases: hr025Cl; HSPC192; ILFS1; KIAA1352; LARS; LARS1; LEURS; LEUS; LFIS; LRS; PIG44; RNTLS
UniProt ID: (Human) Q9P2J5
Entrez Gene ID: (Human) 51520