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LATS1/2 Polyclonal Antibody
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Product Details
BS-4081R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human LATS2.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor. This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: h-warts; Kinase phosphorylated during mitosis protein; large tumor suppressor 2; Large tumor suppressor homolog 1; Large tumor suppressor homolog 2; large tumor suppressor, homolog 2; large tumor supressor, homolog 1; LATS (large tumor suppressor, Drosophila) homolog 1; LATS (large tumor suppressor, Drosophila) homolog 2; LATS, large tumor suppressor, homolog 1; LATS, large tumor suppressor, homolog 2; lats1; lats2; putative serine threonine kinase; serine/threonine kinase KPM; Serine/threonine-protein kinase kpm; Serine/threonine-protein kinase LATS1; Serine/threonine-protein kinase LATS2; similar to Drosophila warts tumor suppressor; unnamed protein product; WARTS protein kinase; Warts-like kinase
Gene Aliases: 4932411G09Rik; AV277261; AW208599; AW228608; KPM; LATS1; LATS2; RGD1564085; WARTS; wts
UniProt ID: (Human) O95835, (Human) Q9NRM7, (Mouse) Q8BYR2, (Mouse) Q7TSJ6
Entrez Gene ID: (Human) 9113, (Human) 26524, (Rat) 308265, (Mouse) 16798, (Mouse) 50523, (Rat) 305922
nucleotide binding
magnesium ion binding
protein kinase activity
protein serine/threonine kinase activity
protein binding
ATP binding
kinase activity
transferase activity
protein kinase binding
estrogen receptor binding
metal ion binding
protein serine kinase activity
transferase activity, transferring phosphorus-containing groups
non-receptor serine/threonine protein kinase
G1/S transition of mitotic cell cycle
G2/M transition of mitotic cell cycle
sister chromatid segregation
inner cell mass cell fate commitment
inner cell mass cellular morphogenesis
protein phosphorylation
protein localization
hormone-mediated signaling pathway
regulation of transforming growth factor beta receptor signaling pathway
keratinocyte differentiation
regulation of actin filament polymerization
regulation of intracellular estrogen receptor signaling pathway
hippo signaling
positive regulation of hippo signaling
positive regulation of apoptotic process
regulation of protein complex assembly
NLRP3 inflammasome complex assembly
mitotic cell cycle phase transition
negative regulation of cyclin-dependent protein serine/threonine kinase activity
regulation of organ growth
cell division
mammary gland epithelial cell differentiation
negative regulation of canonical Wnt signaling pathway
regulation of postsynaptic density assembly
negative regulation of protein localization to nucleus
positive regulation of NLRP3 inflammasome complex assembly
regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
intracellular signal transduction
canonical Wnt signaling pathway
mitotic nuclear division
positive regulation of peptidyl-serine phosphorylation
cellular protein localization
cytoplasmic sequestering of protein
cell cycle
phosphorylation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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