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Proteintech
LAX1 Polyclonal Antibody
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Product Details
21557-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
LAX1 Fusion Protein Ag15599 (77-398 aa encoded by BC069650)
Conjugate
Form
Liquid
Concentration
0.31 mg/mL
Amount
46.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MPLLTLPQT RQRAKNIYDI LPWRQEDLGR HESRSMRIFS TESLLSRNSE SPEHVPSQAG NAFQEHTAHI HATEYAVGIY DNAMVPQMCG NLTPSAHCIN VRASRDCASI SSEDSHDYVN VPTAEEIAET LASTKSPSRN LFVLPSTQKL EFTEERDEGC GDAGDCTSLY SPGAEDSDSL SNGEGSSQIS NDYVNMTGLD LSAIQERQLW VAFQCCRDYE NVPAADPSGS QQQAEKDVPS SNIGHVEDKT DDPGTHVQCV KRTFLASGDY ADFQPFTQSE DSQMKHREEM SNEDSSDYEN VLTAKLGGRD SEQGPGTQLL PDE (77-398 aa encoded by BC069650)
Target Information
Lymphocyte activation gene 1 (LAX1) is located on chromosome 2p16.1 and encodes an immunoregulatory protein that is expressed primarily on lymphocytes, including T cells, B cells, and other immune cells. LAX1 functions as a negative regulator of lymphocyte activation and signaling, playing a crucial role in maintaining immune homeostasis by attenuating excessive immune responses. It acts by modulating signaling pathways that are initiated through surface receptors on lymphocytes, thereby influencing lymphocyte proliferation, cytokine production, and cellular responses during immune activation. Dysregulation of LAX1 expression or function can lead to autoimmune diseases due to impaired control of immune activation. Research into LAX1 focuses on its potential for therapeutic modulation in autoimmune disorders and its role in balancing immune responses, which is essential for maintaining health and preventing pathogenic immune conditions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: LAT-like membrane associated protein; Linker for activation of X cells; Lymphocyte transmembrane adapter 1; Membrane-associated adapter protein LAX; unnamed protein product
Gene Aliases: A530029E09; E430019B13Rik; LAX; LAX1
UniProt ID: (Human) Q8IWV1, (Mouse) Q8BHB3, (Rat) Q5FVQ5
Entrez Gene ID: (Human) 54900, (Mouse) 240754, (Rat) 498232
adaptive immune response
immune system process
immune response
intracellular signal transduction
B cell activation
negative regulation of MAPK cascade
lymphocyte activation
antigen receptor-mediated signaling pathway
negative regulation of T cell activation
regulation of lymphocyte activation
inactivation of MAPK activity
immunoglobulin secretion
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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