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Invitrogen
LBP Polyclonal Antibody
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FIGURE: 1 / 1
LBP Antibody (PA5-79586) in WB
Western blot analysis of LBP in, Lane 1: human Hela whole cell lysates, Lane 2: human Jurkat whole cell lysates, Lane 3: human A549 whole cell lysates, Lane 4: human Raji whole cell lysates, Lane 5: rat liver tissue lysates, Lane 6: mouse liver tissue lysates. Electrophoresis was performed on a 5-20% SDS-PAGE gel at 70V (Stacking gel) / 90V (Resolving gel) for 2-3 hours. The sample well of each lane was loaded with 50 µg of sample under reducing conditions. After Electrophoresis, proteins were transferred to a Nitrocellulose membrane at 15... View More
Product Details
PA5-79586
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
E. coli-derived mouse LBP recombinant protein (Position: V26-R257).
Conjugate
Form
Lyophilized
Concentration
500 µg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS with 4mg trehalose
Contains
0.05mg sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Positive Control - WB: human Hela whole cell, human Jurkat whole cell, human A549 whole cell, human Raji whole cell, rat liver tissue, mouse liver tissue.
Target Information
The LBP protein is involved in the acute-phase immunologic response to gram-negative bacterial infections. Gram-negative bacteria contain a glycolipid, lipopolysaccharide (LPS), on their outer cell wall. Together with bactericidal permeability-increasing protein (BPI), the encoded protein binds LPS and interacts with the CD14 receptor, probably playing a role in regulating LPS-dependent monocyte responses. This protein is part of a family of structurally and functionally related proteins, including BPI, plasma cholesteryl ester transfer protein (CETP), and phospholipid transfer protein (PLTP). Finally, this gene is found on chromosome 20, immediately downstream of the BPI gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: BPI fold containing family D, member 2; LBP; lipopolysaccharide binding protein (LBP) precursor; Lipopolysaccharide-binding protein; LPS-binding protein; unnamed protein product
Gene Aliases: BPIFD2; LBP; Ly88
UniProt ID: (Human) P18428, (Mouse) Q61805
Entrez Gene ID: (Human) 3929, (Mouse) 16803, (Rat) 29469
leukocyte chemotaxis involved in inflammatory response
macrophage activation involved in immune response
immune system process
cell surface pattern recognition receptor signaling pathway
lipid transport
acute-phase response
cellular defense response
opsonization
lipopolysaccharide transport
neutrophil chemotaxis
lipopolysaccharide-mediated signaling pathway
detection of molecule of bacterial origin
response to lipopolysaccharide
negative regulation of tumor necrosis factor production
positive regulation of chemokine production
positive regulation of interleukin-6 production
positive regulation of interleukin-8 production
positive regulation of tumor necrosis factor production
positive regulation of toll-like receptor 4 signaling pathway
defense response to bacterium
positive regulation of macrophage activation
innate immune response
defense response to Gram-negative bacterium
defense response to Gram-positive bacterium
positive regulation of respiratory burst involved in inflammatory response
cellular response to lipopolysaccharide
cellular response to lipoteichoic acid
positive regulation of neutrophil chemotaxis
transport
positive regulation of tumor necrosis factor biosynthetic process
negative regulation of growth of symbiont in host
positive regulation of phagocytosis, engulfment
regulation of membrane permeability
liver development
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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