Immunogen sequence: LGVDCWIDN TRVVYNRSSG LVSNAPGVQI RVPGFGKTYS VEYLDSSKLA GYLHTLVQNL VNNGYVRDET VRAAPYDWRL EPGQQEEYYR KLAGLVEEMH AAYGKPVFLI GHSLGCLHLL YFLLRQPQAW KDRFIDGFIS LGAPWGGSIK PMLVLASGDN QGIPIMSSIK LKEEQRITTT SPWMFPSRMA WPEDHVFIST PSFNYTGRDF QRFFADLHFE EGWYMWLQSR DLLAGLPAPG VEVYCLYGVG LPTPRTYIYD HGFPYTDPVG VLYEDGDDTV ATRSTELCGL WQGRQPQPVH LLPLHGIQHL NMVFSNLTLE HINAILLGAY RQGPPASPTA SPEPPPPE (94-440 aa encoded by BC014781 )
Lecithin: cholesterol acyltransferase (LCAT) is the plasma enzyme responsible for most HDL cholesteryl esters in human plasma. In species with cholesteryl ester transfer protein (CETP) it is also responsible for a significant proportion of VLDL and LDL cholesteryl esters. LCAT, through the esterification of cholesterol, plays a role in the reverse cholesterol transport pathway by facilitating the net movement of cholesterol from peripheral tissues back to the liver for excretion. LCAT deficiency results in low levels of plasma HDL, whereas a transgenic overexpression of LCAT results in increased plasma HDL concentrations.
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Protein Aliases: 1-alkyl-2-acetylglycerophosphocholine esterase; Lecithin-cholesterol acyltransferase; lecithin-cholesterol acyltransferase Lcat; PAF acetylhydrolase; phosphatidylcholine--sterol O-acyltransferase; Phosphatidylcholine-sterol acyltransferase; Phospholipid-cholesterol acyltransferase; Platelet-activating factor acetylhydrolase; testicular secretory protein Li 24
Gene Aliases: AI046659; D8Wsu61e; LCAT
Molecular Function: acyltransferase