Keep as concentrated solution.
Positive Control: 293T, A431, H1299, HeLa, HepG2, Molt-4, Raji.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.
LCK is a member of the Src-family tyrosine kinase, which are essential for signaling through the T-cell receptor (TCR) complex. Upon TCR triggering, LCK phosphorylates the ITAM motives in its zeta subunits establishing binding sites for the SH2 domains of the tyrosine kinase ZAP70, which is also phosphorylated by LCK and activated to generate subsequent signaling platforms by phosphorylation of adaptor LAT. The majority of LCK is localized to the plasma membrane, however, there is also a significant fraction associated with the Golgi apparatus which may contribute to Raf activation under conditions of weak stimulation through the TCR. LCK contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. LCK is also involved in the regulation of apoptosis induced by various stimuli, but not by the death receptors. Diseases associated with LCK include Immunodeficiency 22 and CD45 deficiency. Alternatively splice variants of the LCK gene encoding different isoforms of the protein have been found.
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Protein Aliases: LCK antibody; Leukocyte C-terminal Src kinase; leukocyte C-terminal Src kinase antibody; LSK; LSK antibody; Lymphocyte cell-specific protein-tyrosine kinase; lymphocyte cell-specific protein-tyrosine kinase antibody; lymphocyte-specific protein tyrosine kinase antibody; p56(LSTRA) protein-tyrosine kinase; p56(LSTRA) protein-tyrosine kinase antibody; p56-LCK; p56lck antibody; pp58lck antibody; Protein YT16; Proto-oncogene Lck; proto-oncogene tyrosine-protein kinase LCK; proto-oncogene tyrosine-protein kinase LCK antibody; T cell-specific protein-tyrosine kinase; t cell-specific protein-tyrosine kinase antibody; T-lymphocyte specific protein tyrosine kinase p56lck; T-lymphocyte specific protein tyrosine kinase p56lck antibody; Tyrosine-protein kinase Lck; tyrosine-protein kinase Lck antibody; YT16 antibody
Gene Aliases: IMD22; LCK; LSK; p56lck; pp58lck; YT16
UniProt ID: (Human) P06239
Entrez Gene ID: (Human) 3932