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Invitrogen
LDLRAP1 Polyclonal Antibody
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Product Details
PA5-30505
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the center region of human ARH. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7, with 1% BSA, 20% glycerol
Contains
0.01% thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Recommended positive controls: U87-MG.
Predicted reactivity: Human (99%), Mouse (82%), Rat (83%), Bovine (84%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
The protein encoded by this gene is a cytosolic protein which contains a phosphotyrosine binding (PTD) domain. The PTD domain has been found to interact with the cytoplasmic tail of the LDL receptor. Mutations in this gene lead to LDL receptor malfunction and cause the disorder autosomal recessive hypercholesterolaemia.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Autosomal recessive hypercholesterolemia protein; DKFZp586D0624; LDL receptor adaptor protein; Low density lipoprotein receptor adapter protein 1; MGC34705; RP11-70P17.2; unnamed protein product
Gene Aliases: ARH; ARH1; ARH2; FHCB1; FHCB2; FHCL4; LDLRAP1
UniProt ID: (Human) Q5SW96
Entrez Gene ID: (Human) 26119
beta-amyloid binding
phosphotyrosine binding
protein binding
phosphatidylinositol-4,5-bisphosphate binding
receptor signaling complex scaffold activity
clathrin binding
signaling adaptor activity
AP-2 adaptor complex binding
clathrin adaptor activity
AP-1 adaptor complex binding
low-density lipoprotein particle receptor binding
lipid metabolic process
endocytosis
receptor-mediated endocytosis
steroid metabolic process
cholesterol metabolic process
cholesterol transport
receptor internalization
low-density lipoprotein particle clearance
cholesterol homeostasis
amyloid precursor protein metabolic process
regulation of protein binding
positive regulation of receptor-mediated endocytosis
cellular response to cytokine stimulus
receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport
positive regulation of cholesterol metabolic process
regulation of protein localization to plasma membrane
positive regulation of vascular smooth muscle cell proliferation
positive regulation of low-density lipoprotein particle clearance
positive regulation of receptor-mediated endocytosis involved in cholesterol transport
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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