|Western Blot (WB)||1:1000|
|Tested Species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||KLH conjugated synthetic peptide between 253-281 amino acids from the C-terminal region of human LECT1|
|Purification||Ammonium sulfate precipitation, Size-exclusion - Dialysis|
|Contains||0.09% sodium azide|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
This antibody is predicted to react with bovine, mouse, rat and rabbit based on sequence homology.
LECT1 a glycosylated transmembrane protein that is cleaved to form a mature, secreted protein. The N-terminus of the precursor protein shares characteristics with other surfactant proteins and is sometimes called chondrosurfactant protein although no biological activity has yet been defined for it. The C-terminus of the precursor protein contains a 25 kDa mature protein called leukocyte cell-derived chemotaxin-1 or chondromodulin-1. The mature protein promotes chondrocyte growth and inhibits angiogenesis. This protein is expressed in the avascular zone of prehypertrophic cartilage and its expression decreases during chondrocyte hypertrophy and vascular invasion. The mature protein likely plays a role in endochondral bone development by permitting cartilaginous anlagen to be vascularized and replaced by bone. It may be involved also in the broad control of tissue vascularization during development.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: BRICHOS domain containing 3; ChM-I; CHMI; Chondromodulin; chondromodulin I; chondromodulin-1; Chondromodulin-1 [Precursor]; Chondromodulin-I; LECT1; Leukocyte cell-derived chemotaxin 1; multiple myeloma tumor suppressor 1
Gene Aliases: BRICD3; CHM-I; CHM1; CHMI; CNMD; LECT1; MYETS1
UniProt ID: (Human) O75829
Entrez Gene ID: (Human) 11061
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