Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
Immunogen sequence: NGITGIRFAG GEKCYIKAQV KARIPEVGAV TKQSISSKLE GKIMPVKYEE NSLIWVAVDQ PVKDNSFLSS KVLELCGDLP IFWLKPTYPK EIQRERREVV RKIVPTTTKR PHSGPRSNPG AGRLNNETRP SVQ
Highest antigen sequence identity to the following orthologs: Mouse - 85%, Rat - 85%.
ChM-1 is a cartilage-specific matrix glycoprotein that stimulates the growth of chondrocytes. ChM-1 inhibits angiogenesis by disrupting the tube formation of endothelial cells and thus is responsible for the avascular nature of cartilage. ChM-1 is strongly expressed by the proliferating and hypertrophic zones in the epiphyseal plate of long bones. ChM-1 accumulates in the interterritorial matrix around the lacunae. During development, downregulation of ChM-1 permits angiogenesis and ultimately bone formation on the cartilage template. ChM-1 expression is downregulated in the presence of several growth factors including TGFβ2, FGF2 and PTHLH. ChM-1 expression may also play a role in the hypovascularity and chondroid formation of pleomorphic adenomas. The gene encoding human ChM-1 maps to chromosome 13q14-q21.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: BRICHOS domain containing 3; Chondromodulin; chondromodulin I; chondromodulin-1; chondromodulin-I; Leukocyte cell-derived chemotaxin 1; multiple myeloma tumor suppressor 1
Gene Aliases: BRICD3; CHM-I; CHM1; CHMI; CNMD; LECT1; MYETS1
UniProt ID: (Human) O75829
Entrez Gene ID: (Human) 11061
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