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Invitrogen
LEMD2 Polyclonal Antibody
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FIGURE: 1 / 2
LEMD2 Antibody (PA5-98781) in IHC (P)
Immunohistochemical analysis of LEMD2 in paraffin embedded human kidney tissue using a LEMD2 polyclonal antibody (Product # PA5-98781) at a dilution of 1:300. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detec... View More
Product Details
PA5-98781
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Human LEM domain-containing protein 2 protein (17-204AA)
Conjugate
Form
Liquid
Concentration
3.475 mg/mL
Amount
100 µg
Purification
Protein G
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.03% ProClin 300
Storage conditions
-20°C or -80°C if preferred
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
The LEM (lamina-associated polypeptide-emerin-MAN1) domain is a motif shared by a group of lamin-interacting proteins of the inner nuclear membrane (INM) and nucleoplasm. One such protein, LEMD2 (LEM domain-containing protein 2), is a lamina-associated protein in the INM involved in nuclear structure organization, containing an N-terminal LEM motif, two transmembrane domains, and a MAN1-Src1p C-terminal (MSC) domain. LEMD2 is a truncated paralog of MAN1, lacking the MAN1-specific C-terminal RNA-recognition motif, but like MAN1 is required for myogenic differentiation. Mutations in LEMD2 are thought be among the possible causes of muscle disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: hLEM2; lamina-associated polypeptide-emerin-MAN1 domain containing 2; LEM domain containing 2; LEM domain-containing protein 2; unnamed protein product
Gene Aliases: CTRCT42; dJ482C21.1; LEM2; LEMD2; MARUPS; NET25
UniProt ID: (Human) Q8NC56
Entrez Gene ID: (Human) 221496
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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