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Product Details
12281-1-AP
| Applications | Tested Dilution | Publications |
|---|---|---|
Western Blot (WB) |
1:500-1:2400 | - |
Immunohistochemistry (Paraffin) (IHC (P)) |
1:20-1:200 | - |
Immunocytochemistry (ICC/IF) |
1:10-1:100 | - |
| Product Specifications | |
|---|---|
Species Reactivity |
Human, Mouse, Rat |
Host/Isotype |
Rabbit / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
LEO1 Fusion Protein Ag2932 (1-332 aa encoded by BC018147) |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
0.41 mg/mL |
Purification |
Antigen affinity chromatography |
Storage buffer |
PBS, pH 7.3, with 50% glycerol |
Contains |
0.02% sodium azide |
Storage conditions |
-20°C |
Product Specific Information
Immunogen sequence: MADMEDLFG SDADSEAERK DSDSGSDSDS DQENAASGSN ASGSESDQDE RGDSGQPSNK ELFGDDSEDE GASHHSGSDN HSERSDNRSE ASERSDHEDN DPSDVDQHSG SEAPNDDEDE GHRSDGGSHH SEAEGSEKAH SDDEKWGRED KSDQSDDEKI QNSDDEERAQ GSDEDKLQNS DDDEKMQNTD DEERPQLSDD ERQQLSEEEK ANSDDERPVA SDNDDEKQNS DDEEQPQLSD EEKMQNSDDE RPQASDEEHR HSDDEEEQDH KSESARGSDS EDEVLRMKRK NAIASDSEAD SDTEVPKDNS GTMDLFGGAD DISSGSDGED KPP (1-332 aa encoded by BC018147)
Target Information
Prostaglandin-endoperoxide synthase (PTGS), also known as cyclooxygenase, is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase. There are two isozymes of PTGS: a constitutive PTGS1 and an inducible PTGS2, which differ in their regulation of expression and tissue distribution. This gene encodes the inducible isozyme. It is regulated by specific stimulatory events, suggesting that it is responsible for the prostanoid biosynthesis involved in inflammation and mitogenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Leo1 Paf1/RNA polymerase II complex component; Leo1, Paf1/RNA polymerase II complex component, homolog; Replicative senescence down-regulated leo1-like protein; RNA polymerase-associated protein LEO1
Gene Aliases: Gm185; LEO1; RDL
UniProt ID: (Human) Q8WVC0, (Rat) Q641X2, (Mouse) Q5XJE5
Entrez Gene ID: (Human) 123169, (Rat) 300837, (Mouse) 235497
Molecular Function:
DNA-directed RNA polymerase
RNA metabolism protein
nucleic acid metabolism protein
endodermal cell fate commitment
transcription elongation from RNA polymerase II promoter
mRNA polyadenylation
histone monoubiquitination
Wnt signaling pathway
stem cell population maintenance
positive regulation of mRNA 3'-end processing
positive regulation of transcription elongation from RNA polymerase II promoter
histone H2B ubiquitination
negative regulation of myeloid cell differentiation
positive regulation of transcription from RNA polymerase II promoter
beta-catenin-TCF complex assembly
transcription, DNA-templated
biological_process
regulation of transcription, DNA-templated
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