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Alomone Labs, LTD
LETM1 Polyclonal Antibody
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FIGURE: 1 / 1
LETM1 Antibody (ANT-183-200UL) in WB
Western blot analysis of rat brain membrane (lanes 1 and 5), mouse brain membrane (lanes 2 and 6), human acute lymphoblastic leukemia (MOLT-4) (lanes 3 and 7) and human colorectal adenocarcinoma (HT-29) cell lysates: - 1-4. Anti-LETM1 Antibody (#ANT-183), (1:1500).5-8. Anti-LETM1 Antibody , preincubated with LETM1 Blocking Peptide (#BLP-NT183).
Product Details
ANT-183-200UL
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
(C)KELSKTGDEKYIEE, corresponding to amino acid residues 587-600 of rat LETM1, Intracellular, mitochondrial matrix.
Conjugate
Form
Lyophilized
Concentration
0.8 mg/mL
Amount
160 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 1% BSA
Contains
0.05% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
Target Information
This gene encodes a protein that is localized to the inner mitochondrial membrane. The protein functions to maintain the mitochondrial tubular shapes and is required for normal mitochondrial morphology and cellular viability. Mutations in this gene cause Wolf-Hirschhorn syndrome, a complex malformation syndrome caused by the deletion of parts of the distal short arm of chromosome 4. Related pseudogenes have been identified on chromosomes 8, 15 and 19.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Electroneutral mitochondrial K(+)/H(+)exchanger; KHE; LETM1 and EF-hand domain-containing protein 1, mitochondrial; leucine zipper-EF-hand containing transmembrane protein 1; Leucine zipper-EF-hand-containing transmembrane protein 1; Mdm38 homolog; Mitochondrial proton/calcium exchanger protein; unnamed protein product
Gene Aliases: CONDMIM; KHE; LETM1; Mdm38; SLC55A1
UniProt ID: (Human) O95202, (Rat) Q5XIN6, (Mouse) Q9Z2I0
Entrez Gene ID: (Human) 3954, (Rat) 305457, (Mouse) 56384
ion transport
potassium ion transport
calcium ion transport
mitochondrial calcium ion transport
mitochondrion organization
inner mitochondrial membrane organization
protein hexamerization
cristae formation
protein homooligomerization
mitochondrial calcium ion homeostasis
negative regulation of mitochondrial calcium ion concentration
calcium export from the mitochondrion
mitochondrial potassium ion transmembrane transport
regulation of cellular hyperosmotic salinity response
hydrogen ion transmembrane transport
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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