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Invitrogen
LGP2 Polyclonal Antibody
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Product Details
PA5-109635
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein (or fragment).
Conjugate
Form
Liquid
Concentration
9.77 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
Anti-viral innate immune responses are triggered by pathogen-associated molecular patters (such as the accumulation of intracellular nucleic acids resulting from virus infections) and represent the first line of defense against numerous infectious organisms. The Toll-like receptors (TLR) 3, 7, 8, and 9 are expressed in immune cells and function as transmembrane pattern recognition receptors to detect foreign nucleic acids. Other proteins that play similar roles, such as RIG-1 and MDA5 are members of a CARD-helicase family and are expressed in the cytoplasm. A third protein, LGP2, is similar to RIG-1 and MDA5, except for lacking a homologous CARD domain. It is thought to act as an element of negative-feedback regulation of intracellular antiviral signaling. At least four isoforms of LGP2 are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ATP-dependent helicase LGP2; ATP-dependent RNA helicase DHX58; DEXH (Asp-Glu-X-His) box polypeptide 58; ortholog of mouse D11lgp2; probable ATP-dependent helicase LGP2; probable ATP-dependent RNA helicase DHX58; Protein D11Lgp2; Protein D11Lgp2 homolog; RIG-I-like receptor 3; RIG-I-like receptor LGP2; RLR; RLR-3; RNA helicase LGP2
Gene Aliases: B430001I08Rik; D11LGP2; D11LGP2E; DHX58; LGP2; LPG2; RGD1310093; RLR-3
UniProt ID: (Human) Q96C10, (Mouse) Q99J87
Entrez Gene ID: (Human) 79132, (Mouse) 80861, (Rat) 303538
response to virus
negative regulation of type I interferon production
positive regulation of type I interferon production
negative regulation of MDA-5 signaling pathway
negative regulation of RIG-I signaling pathway
innate immune response
regulation of innate immune response
negative regulation of innate immune response
defense response to virus
positive regulation of MDA-5 signaling pathway
positive regulation of RIG-I signaling pathway
immune system process
metabolic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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