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Invitrogen
LHR Polyclonal Antibody
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FIGURE: 1 / 3
LHR Antibody (PA5-115508) in ICC/IF
Immunocytochemistry analysis of LHR in HeLa cells. Samples were treated with PFA, permeabilized in 0.1% Triton X-100, blocked in 10% serum (45 min at 25°C), and incubated with polyclonal antibody (Product # PA5-115508) at a dilution of 1:200 (1 hr at 37°C). Secondary staining was applied with mouse anti-beta tubulin; AlexaFluor 594 conjugated goat anti-rabbit IgG (Red); AlexaFluor 88 conjugated goat anti-mouse IgG (Green) and DAPI (blue) using a dilution of 1:200 (1 hr at 37°C).
Product Details
PA5-115508
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
C. elegans
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human LHCGR(Accession P22888), corresponding to amino acid residues Y275-E325.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total LHR.
Target Information
LHCGR encodes the receptor for both luteinizing hormone and choriogonadotropin. It is family 1 of G-protein coupled receptors, FSH/LSH/TSH superfamily, and its basic function is acting as luteinizing hormone/choriogonadotropin receptor (gonadotropin receptor). Regulating the development and function of Leyding cells in males. It also plays a role in male secondary sexual characterdevelopment. Mutations in this gonadotropinreceptor results in disorders of male secondary sexual characteristic development, such as familial male precocious puperty and male pseudohermaphtoditism.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: HCG receptor; hypergonadotropic hypogonadism; LH/CG-R; LHR; LSH-R; Luteinizing hormone receptor; Lutropin receptor; Lutropin-choriogonadotropic hormone receptor; lutropin/choriogonadotropin receptor
Gene Aliases: Gpcr19-rs1; HHG; LCGR; LGR2; LH-R; LH/CG-R; LH/CGR; LHCGR; LHR; LHRHR; LSH-R; ULG5
UniProt ID: (Human) P22888, (Mouse) P30730
Entrez Gene ID: (Human) 3973, (Mouse) 16867
luteinizing hormone receptor activity
G-protein coupled peptide receptor activity
choriogonadotropin hormone receptor activity
choriogonadotropin hormone binding
signal transducer activity
G-protein coupled receptor activity
protein-hormone receptor activity
peptide hormone binding
identical protein binding
protein homodimerization activity
ATPase binding
G-protein coupled receptor
G-protein coupled receptor signaling pathway
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
adenylate cyclase-activating G-protein coupled receptor signaling pathway
activation of adenylate cyclase activity
phospholipase C-activating G-protein coupled receptor signaling pathway
male gonad development
hormone-mediated signaling pathway
ovulation cycle process
male genitalia development
positive regulation of inositol trisphosphate biosynthetic process
luteinizing hormone signaling pathway
positive regulation of cAMP-mediated signaling
cognition
cellular response to gonadotropin stimulus
ovarian follicle development
protein targeting to lysosome
signal transduction
adenylate cyclase-modulating G-protein coupled receptor signaling pathway
spermatogenesis
female gonad development
positive regulation of calcium ion transport into cytosol
development of secondary male sexual characteristics
positive regulation of hormone biosynthetic process
arachidonic acid secretion
positive regulation of calcium-mediated signaling
positive regulation of release of sequestered calcium ion into cytosol
uterus development
seminiferous tubule development
regulation of steroid hormone biosynthetic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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