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Invitrogen

LIF Polyclonal Antibody

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LIF Polyclonal Antibody

Product Details

PA5-79599

Applications
Tested Dilution
Publications

Western Blot (WB)

0.1-0.5 µg/mL
-

ELISA (ELISA)

1-5 µg/mL (capture)
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

E. coli-derived mouse LIF recombinant protein (Position: S24-F203).
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

500 µg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS with 4mg trehalose

Contains

0.05mg sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2746714

Product Specific Information

Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.

Positive Control - WB: rat brain tissue, rat heart tissue, rat liver tissue, rat kidney tissue, human Hela cell, human placenta tissue, human Jurkat cell, mouse liver tissuemouse kidney tissue.

Target Information

Leukemia inhibitory factor (LIF) is a 20 kDa protein that belongs to the IL-6 receptor family. It binds to a heterodimeric membrane receptor made up of a LIF-specific subunit, gp190 or LIFR, and the subunit gp130, which is shared with the other members of the IL-6 family. LIF expression has been observed in various tissues including thymus, lung, and neuronal tissue. LIF can be up-regulated by pro-inflammatory cytokines such as TNFα and IL-17, and elevated levels of LIF have been found in cases of rheumatoid arthritis, neural injury, systemic inflammation, and tuberculosis. LIF displays diverse biological effects, but is best known for its ability to inhibit the differentiation of embryonic stem cells in mice and contribute to stem cell self-renewal.Human and mouse LIF share 79% sequence homology and exhibit cross-species activity. However, LIF inhibition of stem cell differentiation appears to be mouse-specific.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: cholinergic differentiation factor; cholinergic neuronal differentiation factor; D factor; differentiation inhibitory activity; differentiation-inducing factor; Differentiation-stimulating factor; hepatocyte-stimulating factor III; human interleukin in DA cells; Leukemia inhibitory factor; leukemia inhibitory factor (cholinergic differentiation factor); LIF; Melanoma-derived LPL inhibitor; MLPLI; myeloid leukaemia inhibitory factor; unnamed protein product

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Gene Aliases: CDF; DIA; HILDA; LIF; MLPLI

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UniProt ID: (Human) P15018, (Mouse) P09056

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Entrez Gene ID: (Human) 3976, (Mouse) 16878, (Rat) 60584

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Function(s)
receptor binding cytokine activity leukemia inhibitory factor receptor binding protein binding growth factor activity transcription factor activity, RNA polymerase II transcription factor recruiting cytokine intercellular signal molecule
Process(es)
cell morphogenesis response to hypoxia blood vessel remodeling immune response embryo implantation cell proliferation positive regulation of cell proliferation negative regulation of cell proliferation gene expression positive regulation of gene expression regulation of cell communication regulation of signaling cell differentiation macrophage differentiation lung development positive regulation of peptidyl-serine phosphorylation positive regulation of cell adhesion mediated by integrin somatic stem cell population maintenance positive regulation of MAPK cascade regulation of cell differentiation positive regulation of macrophage differentiation negative regulation of meiotic nuclear division positive regulation of transcription from RNA polymerase II promoter decidualization negative regulation of hormone secretion fibroblast proliferation positive regulation of fibroblast proliferation lung alveolus development muscle organ morphogenesis neuron development positive regulation of astrocyte differentiation leukemia inhibitory factor signaling pathway stem cell differentiation positive regulation of peptidyl-tyrosine phosphorylation positive regulation of multicellular organismal process maternal process involved in female pregnancy lung vasculature development lung lobe morphogenesis trophoblast giant cell differentiation negative regulation of ERK1 and ERK2 cascade positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis regulation of metanephric nephron tubule epithelial cell differentiation receptor signaling pathway via STAT meiotic nuclear division positive regulation of STAT cascade regulation of multicellular organismal development transcription from RNA polymerase II promoter positive regulation of neuron projection development negative regulation of angiogenesis stem cell population maintenance organ regeneration positive regulation of peptidyl-serine phosphorylation of STAT protein tyrosine phosphorylation of Stat3 protein positive regulation of tyrosine phosphorylation of Stat1 protein positive regulation of tyrosine phosphorylation of Stat3 protein astrocyte differentiation positive regulation of corticotropin secretion retina development in camera-type eye transdifferentiation spongiotrophoblast differentiation positive regulation of protein localization to nucleus positive regulation of histone H3-K27 acetylation regulation of RNA polymerase II regulatory region sequence-specific DNA binding
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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